DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg3 and nlgn2b

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_001159808.1	Gene:	nlgn2b / 100002407	ZFINID:	ZDB-GENE-090918-3	Length:	860	Species:	Danio rerio

Alignment Length:	897	Identity:	297/897 - (33%)
Similarity:	423/897 - (47%)	Gaps:	183/897 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|..|.:.||..:|:...|.|||.|.|:|||:||||..||.||.:...|..::.|.:|:||||
Zfish    53 MVTTGYGKLRGVRKELNNEILGPVEQYLGVPYATPPVGERRFQPPEAPGSWQEIRNATQFAPVCP 117

  Fly   222 QR----LPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSS 282
            |.    ||:|        .:|....:.|.....|:|||||||||||:|||.:.|..
Zfish   118 QNIHGVLPEI--------MLPVWFTDNLDAAAAYVQNQSEDCLYLNVYVPTEDGPL--------- 165

  Fly   283 SAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQIL 347
                       :.....||.............|.||::|:||.|:...:||.:|.||||:||.::
Zfish   166 -----------TKKHDESSMNRPRDEDIRDRRKKPVMLFIHGGSFMEGTGNMFDASVLAAYGNVI 219

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            |||:||||||||||::. |:.:|  .||||:|.|.||.||.|||..|||||..||:.|.|.||:|
Zfish   220 VVTMNYRLGVLGFLSSG-DQSAK--GNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASC 281

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCA-SDLPHAHLMKCLRE 476
            |:.||.|.. .|| ||.|||..|||.::.||:...|..|..|:|..|.|: ||.  |.|:.|||.
Zfish   282 VNLLILSHH-SEG-LFQRAIAQSGSAISSWSVNYRPLMYTKILAKKVGCSYSDT--ADLVDCLRR 342

  Fly   477 KTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIA 541
            |:..:|:...::|..:..||||.:|      ||.||..|.
Zfish   343 KSYRELVDQDVQPARYHIAFGPVVD------GDVVPDDPE------------------------- 376

  Fly   542 AAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYV 606
                          :||::   .:...||::.||.:.|.....:..:.:.||.|......:..:|
Zfish   377 --------------ILMQQ---GEFLNYDILLGVNQGEGLKFVDDNEGEEGISAASFDYTISNFV 424

  Fly   607 RNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDLHSAD 665
            .|.|.:.     |.|   ||...||||..  :...::|.:||.|| :|.|.||||..|..||:..
Zfish   425 DNLYGYPEGKDILRE---TIKFMYTDWAD--RDNGDMRRKTLLALFTDHQWVAPAVATAKLHAEF 484

  Fly   666 HRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWS 730
            ....|.|.|.:..:....|:.....||:::||:||.|:||....|..|::|.:|.||.|||.||:
Zfish   485 QSPVYFYTFHHHCQTEARPEWADAAHGDEIPYVFGVPMVGATELFPCNFSKNDIMLSAVVMTYWT 549

  Fly   731 NFVRTGNPN----EQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFW 791
            ||.:||:||    :..:..|   .:.:|::.:.||.:.|..|:||:...||:::::|||::::||
Zfish   550 NFAKTGDPNIPVPQDTKFIH---TKPNRFEEVIWTKFSSKDKQYLHIGLKPRIRDNYRANKVAFW 611

  Fly   792 LNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFTNQV 856
            |.|:|.|            |.:||:      ||:..:..|...|:.......|
Zfish   612 LELVPHL------------HTIHDE------IPTYTTQLPPGAPHRPGWKGTA------------ 646

  Fly   857 FSLLNLSSPSSSLQRNGTRYGGGKIYP--DDMMDGDHAGGA---ASASQDSDGFAAYSTALSVTI 916
                  .||.:    ..||:.....||  .|:...:|....   .|.::|      |||.||||:
Zfish   647 ------QSPGT----RSTRHPTVSTYPPDPDLEGSEHPPERFPFPSNTRD------YSTELSVTV 695

  Fly   917 AIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQEN--------GQMPNNICGDLETLTIH 973
            |:|.|||.||||.||.:||:|||......|...:|..|..        |..|:|   ||
Zfish   696 AVGASLLFLNVLAFAALYYKRDKRHELLQRRHRRLSPQRGAVPGVGIVGGPPHN---DL------ 751

  Fly   974 AKSDPATILSHHHAMQH----HQLPPPE---FADIPHRAPP--PPKHMKSLQ 1016
            |.|....::|.....|.    |..|.|.   ..|:....||  ||.:..:|:
Zfish   752 ALSQEEELMSLQMKQQRVELDHGTPLPTRGLHGDLEPLRPPVCPPDYTLALR 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	229/648 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	53/96 (55%)
nlgn2b	NP_001159808.1	COesterase	47..611	CDD:278561	229/648 (35%)
nlgn2b	NP_001159808.1	Aes	<181..>279	CDD:223730	53/100 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575320
Domainoid	1	1.000	364	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69317
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm6461
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760