Protein Alignment SMAD6 and Med

DIOPT Version :10

• Sequence 1: NP_005576.3
• Gene: SMAD6 / 4091
• HGNCID: 6772
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Alignment Length: 782
• Identity: 144/782 - (18%)
• Similarity: 205/782 - (26%)
• Gaps: 410/782 - (52%)

Human    87 GG----PPRPMSEPGAGAGSSLL--DVAE-PGGPGWLPES--DCETVTCCLFSERDAAGAPRDAS 142
            ||    ||..|.  ||.|...::  |:.: |..|...|.|  .|.::...|...|.
  Fly     3 GGSGACPPAHMY--GAVAPQDIIVRDMVQMPPPPSNAPTSADACLSIVHSLMCHRQ--------- 56

Human   143 DPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKER--SLDTLLEAVESRGGVPGGC 205
                        ||.|          |...|....||:|:|||:  .||:|:.|:.:.|..|..|
  Fly    57 ------------GGES----------EGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99

Human   206 VLVPR---ADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFS 267
            |.:.|   ..|::.|:...|.::..|::||||| |..|||.:..| :||......:||.||||:.
  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDL-HKNELKHVKYC-AFAFDLKCDSVCVNPYHYE 162

Human   268 RLCGP------------------------------------------------------------ 272
            |:..|
  Fly   163 RVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPS 227

Human   273 ----------------------------------------------------------------- 272
                                                                             
  Fly   228 EYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQ 292

Human   273 -----------------------------ESPPPPYSRL--------------SPRDEYKPLDLS 294
                                         .:||||..:.              ||.|....|.:.
  Fly   293 QAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQ 357

Human   295 D---------------------------------------------------------------- 295
            .
  Fly   358 QQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVH 422

Human   296 ----------------------------------------------------------------- 295
                                                                             
  Fly   423 AQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGP 487

Human   296 STLSYTETEATNSLITAPGEFSDASMSPD-----------------------ATKPSHWCSVAYW 337
            :||:||::.......:.||.|.::|:|.|                       ...|.:|||:||:
  Fly   488 NTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYF 552

Human   338 EHRTRVGRLYAVYDQAVSI----FYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPD 398
            |..|:||..:.|.....::    :.|...|:.||||.|:...|:|...|.|..||.|:.|....:
  Fly   553 ELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGE 617

Human   399 G-VWAYNRGEHPIFVNSPTLDAPGGRAL--VVRKVPPGYSIKVFDFER---------SGLQHAPE 451
            | ||.....::.:||.|..||...||..  .|.|:.|...|||||..:         :..|.|..
  Fly   618 GDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAA 682

Human   452 PDAADGPYDPNS-------------------------VRISFAKGWGPCYSRQFITSCPCWLEIL 491
            ..||......|.                         :|:||.|||||.|.||.|...|||:|:.
  Fly   683 AQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVH 747

Human   492 LN 493
            |:
  Fly   748 LH 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD6	NP_005576.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..116		11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..156		0/19 (0%)
		MH1_SMAD_6	160..273	CDD:199817	41/271 (15%)
		MH2_SMAD_6	322..494	CDD:199824	68/236 (29%)
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	46/156 (29%)
		MH2_SMAD_4	543..760	CDD:199823	66/207 (32%)