DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMAD6 and Mad

DIOPT Version :9

Sequence 1:	NP_005576.3	Gene:	SMAD6 / 4091	HGNCID:	6772	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	117/393 - (29%)
Similarity:	175/393 - (44%)	Gaps:	84/393 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   178 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRWPDLQH 237
            ||:|:||:|  :::.|..|: |..|.|..||.:||:   .|::..:...|.::..|::||||||.
  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQS 183

Human   238 AVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPP---PPYSRLSP--------------- 284
            ..|||||..| .:..:|....||.||||:.|:..|..||   |.:|..:|
  Fly   184 HHELKPLELC-QYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSM 247

Human   285 -------RDEYKPLDLSDSTLSYTETEATNSLITAP--------------------------GEF 316
                   ...:....||.|..|.....:.||...:|                          |:.
  Fly   248 PHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQL 312

Human   317 SDASMSPDA----TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGF----------C 367
            .||.|...|    ::|:.|.|:||:|...|||.::...:.:|.:       .||          |
  Fly   313 LDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCC 370

Human   368 LGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVP 431
            ||||:...|:.::..||..||.|:.|......|:|....:..|||.|...:...| ....|.|:|
  Fly   371 LGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIP 435

Human   432 PGYSIKVF-DFERSGLQHAPEPDAADGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILL 492
            ||.|:|:| :.|.:.|......:..:..|:..   ::|:||.||||..|.||.:||.|||:||.|
  Fly   436 PGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL 500

Human   493 NNP 495
            :.|
  Fly   501 HGP 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMAD6	NP_005576.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		MH1_SMAD_6	160..273	CDD:199817	38/99 (38%)
		MH2_SMAD_6	322..494	CDD:199824	61/190 (32%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	38/97 (39%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	61/186 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810