DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMAD6 and Smox

DIOPT Version :10

Sequence 1:NP_005576.3 Gene:SMAD6 / 4091 HGNCID:6772 Length:496 Species:Homo sapiens
Sequence 2:NP_511079.1 Gene:Smox / 31738 FlyBaseID:FBgn0025800 Length:486 Species:Drosophila melanogaster


Alignment Length:438 Identity:122/438 - (27%)
Similarity:178/438 - (40%) Gaps:128/438 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   178 SLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAP---------PQLLLGRLFRWP 233
            :|:|::|:.|....||...|.......||.|||:      :|||         |.::..||:|||
  Fly    35 NLVKKIKKNSQLEELERAISTQNCQTRCVTVPRS------KPAPAGEHLRKGLPHVIYCRLWRWP 93

Human   234 DLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSR----LCGPES-PPPPYS------------- 280
            |||...|||||..| .:|.......:|.||||:.:    :..|:| |.||.|             
  Fly    94 DLQSQNELKPLDHC-EYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDYPLDNHTHQI 157

Human   281 --------------RLSPRDEYK------PLDLSDSTLSYTETEA------------TNSLITA- 312
                          .||| .:|.      |:.:|.|..|...|.|            ::|..:| 
  Fly   158 PNNTDYNAAIIRSASLSP-PQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASAY 221

Human   313 ---------------------------------PGEFSD-------------ASMSPDAT----- 326
                                             ||..|:             :.::|.|.     
  Fly   222 QQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNMSRLTPPADAAPVM 286

Human   327 --KPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRSKI 387
              :|:.|||::|:|..||||..:.....::::  |.|......||||.|:...|:|.|.:||..|
  Fly   287 YHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHI 351

Human   388 GFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVF-DFERSGLQHAP 450
            |.|:.|......|:|....:..|||.||..:.. |.....|.|:|||.::|:| :.|.:.|....
  Fly   352 GKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQS 416

Human   451 EPDAADGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 495
            .....:..|...   ::|:||.||||..|.||.:||.|||:|:.||.|
  Fly   417 VSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMAD6NP_005576.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..156
MH1_SMAD_6 160..273 CDD:199817 36/107 (34%)
MH2_SMAD_6 322..494 CDD:199824 63/185 (34%)
SmoxNP_511079.1 MH1_R-SMAD 7..130 CDD:199812 36/101 (36%)
MH2_SMAD_2_3 285..475 CDD:199826 63/180 (35%)
Blue background indicates that the domain is not in the aligned region.

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