DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMAD6 and sma-3

DIOPT Version :9

Sequence 1:	NP_005576.3	Gene:	SMAD6 / 4091	HGNCID:	6772	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_498493.1	Gene:	sma-3 / 175955	WormBaseID:	WBGene00004857	Length:	393	Species:	Caenorhabditis elegans

Alignment Length:	348	Identity:	100/348 - (28%)
Similarity:	165/348 - (47%)	Gaps:	41/348 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   178 SLLKRLKERS--LDTL--LEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRWPDL 235
            :|:|:||:::  ..||  ||.|.:.......|:.:.::   .|::..:...|.::..|::||||:
Worm    34 ALVKKLKKKNNGCGTLEDLECVLANPCTNSRCITIAKSLDGRLQVSHKKGLPHVIYCRVWRWPDI 98

Human   236 QHAVELKPLCGC-HSFAAAADGPTVCCNPYHFSRLCGPE----SPPPPYSRLSPRDEYKPLDLSD 295
            ....||:.:..| :.:.:::....:|.||||:.||..|:    |.|.|....||
Worm    99 SSPHELRSIDTCSYPYESSSKTMYICINPYHYQRLSRPQGLNSSMPSPQPISSP----------- 152

Human   296 STLSYTETEATNSLITAP---------GEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYD 351
            :|:..:...:|.|..::|         ||.......|....|..|..:.|:|..:|||.::.:.:
Worm   153 NTIWQSSGSSTASCASSPSPSVFSEDGGEVQVHQRPPPFRHPKSWAQITYFELNSRVGEVFKLVN 217

Human   352 QAVSI-FYDLPQGSG--FCLGQLNLEQRSESVRRTRSKIGFGILLSKEPD--GVWAYNRGEHPIF 411
            .:::: .|..|..|.  .|||||....|:.::..||..||.||.|..:.|  .:...|..:.|:|
Worm   218 LSITVDGYTNPSNSNTRICLGQLTNVNRNGTIENTRMHIGKGIQLDNKEDQMHIMITNNSDMPVF 282

Human   412 VNSPTLDAPGGRALV-VRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNS---VRISFAKGW 472
            |.|...:......|| |.::||...:.||:|...........:.:||..:.:.   :||||.|||
Worm   283 VQSKNTNLMMNMPLVKVCRIPPHSQLCVFEFNLFFQMLEQSCNDSDGLNELSKHCFIRISFVKGW 347

Human   473 GPCYSRQFITSCPCWLEILLNNP 495
            |..|.||.:||.|||||:.||.|
Worm   348 GEDYPRQDVTSTPCWLELRLNVP 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMAD6	NP_005576.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		MH1_SMAD_6	160..273	CDD:199817	27/102 (26%)
		MH2_SMAD_6	322..494	CDD:199824	59/180 (33%)
sma-3	NP_498493.1	MH1	10..133	CDD:260161	25/98 (26%)
sma-3	NP_498493.1	MH2_R-SMAD	197..379	CDD:199820	59/174 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003707
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810