DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMAD6 and Smad6

DIOPT Version :9

Sequence 1:	NP_005576.3	Gene:	SMAD6 / 4091	HGNCID:	6772	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_032568.3	Gene:	Smad6 / 17130	MGIID:	1336883	Length:	495	Species:	Mus musculus

Alignment Length:	499	Identity:	465/499 - (93%)
Similarity:	470/499 - (94%)	Gaps:	7/499 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAP 65
            |||||||||||||||||||||||| |||||||.||||||||||||||||||||||.|||||.|||
Mouse     1 MFRSKRSGLVRRLWRSRVVPDREE-GSGGGGGVDEDGSLGSRAEPAPRAREGGGCSRSEVRSVAP 64

Human    66 RRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFS 130
            ||||||||.|||..||||||.||.|||:||.|||||.|.||||||||||||||||||||||||||
Mouse    65 RRPRDAVGPRGAAIAGRRRRTGGLPRPVSESGAGAGGSPLDVAEPGGPGWLPESDCETVTCCLFS 129

Human   131 ERDAAGAPRDASDPLAGAALEP--AGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLE 193
            ||||||||||:.||.|..:.||  .||.|||||||||||||||||||||||||||||||||||||
Mouse   130 ERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLE 194

Human   194 AVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPT 258
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
Mouse   195 AVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFTAAADGPT 259

Human   259 VCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSP 323
            ||||||||||||||||||||||||||.|:||||||||||||||||||||||||||||||||||||
Mouse   260 VCCNPYHFSRLCGPESPPPPYSRLSPPDQYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSP 324

Human   324 DATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIG 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   325 DATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIG 389

Human   389 FGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSG-LQHAPEP 452
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||
Mouse   390 FGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHA--- 451

Human   453 DAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR 496
            |||.|||||:||||||||||||||||||||||||||||||||.|
Mouse   452 DAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMAD6	NP_005576.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..116		101/114 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156		11/21 (52%)
		MH1_SMAD_6	160..273	CDD:199817	111/112 (99%)
		MH2_SMAD_6	322..494	CDD:199824	166/172 (97%)
Smad6	NP_032568.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115		101/114 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..161		16/27 (59%)
		MH1_SMAD_6	161..274	CDD:199817	111/112 (99%)
		MH2_SMAD_6	323..493	CDD:199824	166/172 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83971839
Domainoid	1	1.000	331	1.000	Domainoid score	I14440
eggNOG	1	0.900	-	-		E1_KOG3701
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4079
Inparanoid	1	1.050	939	1.000	Inparanoid score	I6363
Isobase	1	0.950	-	0	Normalized mean entropy	S6478
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50070
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003707
OrthoInspector	1	1.000	-	-		oto125241
orthoMCL	1	0.900	-	-		OOG6_109794
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5077
SonicParanoid	1	1.000	-	-		X6247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240