DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est1 and CES2

DIOPT Version :9

Sequence 1:NP_524269.3 Gene:alpha-Est1 / 40909 FlyBaseID:FBgn0015568 Length:565 Species:Drosophila melanogaster
Sequence 2:NP_001352334.1 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:595 Identity:175/595 - (29%)
Similarity:240/595 - (40%) Gaps:144/595 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 YRLGTKQTKVVC--------------------TRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPV 69
            :||..:.:.|.|                    |..|||.|..............|.|||||:||:
Human     4 HRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPL 68

  Fly    70 GELRFRAPQPPHPWLGVRDCTYPRAKPMQKHFVLSIVEG---------------SEDCLYLNVYS 119
            |.|||..|:||..|.||||.|...|..:|.   |:.||.               |||||||::|:
Human    69 GPLRFAPPEPPESWSGVRDGTTHPAMCLQD---LTAVESEFLSQFNMTFPSDSMSEDCLYLSIYT 130

  Fly   120 -KRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQ-QDVVVVTFNYRVGALGFLSLADRDLD 182
             ........|||:|||:||...||.|  ..|....... ::||||...||:|.|||.|..|:  .
Human   131 PAHSHEGSNLPVMVWIHGGALVFGMA--SLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDK--H 191

  Fly   183 VPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSG- 246
            ..||.|..|||.||||:.||||.|.|:|..:|:.|||||..||.:|:.:..::||||.|||:|| 
Human   192 ATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGV 256

  Fly   247 ----SMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQY 307
                .:....|:..|...|...||.                   .....|..|......:|....
Human   257 ALLPGLIASSADVISTVVANLSACD-------------------QVDSEALVGCLRGKSKEEILA 302

  Fly   308 VLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFE 372
            :..||..:  |.:.....|||..:|:|..|....:|.|:|.|:.|                  |.
Human   303 INKPFKMI--PGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNE------------------FG 347

  Fly   373 VLIPREIREKSTQSHLK----------------------DLLRQFKV-DNFDDATRGRMEFNE-- 412
            .|||:.:|...||..:.                      ||||:..: ||.|..|. :.:|.|  
Human   348 WLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTL-QAQFQEMM 411

  Fly   413 -----CLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHA 472
                 .:..|.|.||          :.|.|   |.|.|.|........:.|.    .|:: ..|.
Human   412 ADSMFVIPALQVAHF----------QCSRA---PVYFYEFQHQPSWLKNIRP----PHMK-ADHG 458

  Fly   473 DDLSYLFYHIL-ANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLN 536
            |:|.::|.... .|.:..:..|.|..::::..|..||||.|||..  |...|...|::...:.||
Human   459 DELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGE--GLPHWPLFDQEEQYLQLN 521

  Fly   537 ----IGKQLE 542
                :|:.|:
Human   522 LQPAVGRALK 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est1NP_524269.3 COesterase 28..541 CDD:278561 172/589 (29%)
Aes <117..>233 CDD:223730 51/117 (44%)
CES2NP_001352334.1 COesterase 30..538 CDD:306613 171/569 (30%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142687
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 216 1.000 Inparanoid score I3612
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100080
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.690

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