Protein Alignment alpha-Est1 and TG

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 130/534 - (24%)
• Similarity: 209/534 - (39%)
• Gaps: 166/534 - (31%)

  Fly    59 FEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQKHFVLSIVEG-SEDCLYLNVYSKRL 122
            |.|:|:|.||:.|.||:||:|.: |.|..|.:.|||...|.....|...| |||||||||:
Human  2228 FLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVF---- 2287

  Fly   123 RSDKPLP--------VIVWIYG--------------GGFQFGEAGRDFYSPDYFMQQDVVVVTFN 165
                 :|        |:|:.:.              |.| ....|            :::|||.:
Human  2288 -----IPQNVAPNASVLVFFHNTMDREESEGWPAIDGSF-LAAVG------------NLIVVTAS 2334

  Fly   166 YRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGA--ASVHAL 228
            ||||..||||....  :|.||.||.|||.||.|:..:|..|.|||:.:::..:..||  ||:|.|
Human  2335 YRVGVFGFLSSGSG--EVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLL 2397

  Fly   229 MTTEQTRGLFHKAIMQSGSMFC-------EWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKA 286
            ........||.:|::..||...       |.|.:.:...|..::|.:..|     :||...|::.
Human  2398 TARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSS-----QEVVSCLRQK 2457

  Fly   287 PASEMAAQGITLVSQEERRQYVLFPF---TPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGG 348
            ||:       .|...:.:...|..||   .||::.:..|:   |.. |.:....| .::.|::|.
Human  2458 PAN-------VLNDAQTKLLAVSGPFHYWGPVIDGHFLRE---PPA-RALKRSLW-VEVDLLIGS 2510

  Fly   349 NSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNEC 413
            :..:||.:                       |.|:        ::||      :.:|||..
Human  2511 SQDDGLIN-----------------------RAKA--------VKQF------EESRGRTS---- 2534

  Fly   414 LHILSVKHFWHGIHRTVLARLSHA--PATPTYLYRFDVDSPHFNHFRQ----------VMC---- 462
                |...|:..:..::....|.|  .|..|:.|..:..:..:..|.:          ::|
Human  2535 ----SKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIID 2595

  Fly   463 -----GKHVRG---VSHADD----------------LSYLFYHILANKVDKSSMEYQTIQ-RLVG 502
                 .|..||   :.||.:                |...||.....:.   |:|.:::. :::.
Human  2596 MASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQF---SLEEKSLSLKIMQ 2657

  Fly   503 MWVAFARNDNPNCP 516
            .:..|.|:.|||.|
Human  2658 YFSHFIRSGNPNYP 2671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	130/534 (24%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		130/534 (24%)
		COesterase	2197..2718	CDD:395084	130/534 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768