DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and TG

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	534	Identity:	130/534 - (24%)
Similarity:	209/534 - (39%)	Gaps:	166/534 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQKHFVLSIVEG-SEDCLYLNVYSKRL 122
            |.|:|:|.||:.|.||:||:|.: |.|..|.:.|||...|.....|...| |||||||||:
Human  2228 FLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVF---- 2287

  Fly   123 RSDKPLP--------VIVWIYG--------------GGFQFGEAGRDFYSPDYFMQQDVVVVTFN 165
                 :|        |:|:.:.              |.| ....|            :::|||.:
Human  2288 -----IPQNVAPNASVLVFFHNTMDREESEGWPAIDGSF-LAAVG------------NLIVVTAS 2334

  Fly   166 YRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGA--ASVHAL 228
            ||||..||||....  :|.||.||.|||.||.|:..:|..|.|||:.:::..:..||  ||:|.|
Human  2335 YRVGVFGFLSSGSG--EVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLL 2397

  Fly   229 MTTEQTRGLFHKAIMQSGSMFC-------EWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKA 286
            ........||.:|::..||...       |.|.:.:...|..::|.:..|     :||...|::.
Human  2398 TARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSS-----QEVVSCLRQK 2457

  Fly   287 PASEMAAQGITLVSQEERRQYVLFPF---TPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGG 348
            ||:       .|...:.:...|..||   .||::.:..|:   |.. |.:....| .::.|::|.
Human  2458 PAN-------VLNDAQTKLLAVSGPFHYWGPVIDGHFLRE---PPA-RALKRSLW-VEVDLLIGS 2510

  Fly   349 NSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNEC 413
            :..:||.:                       |.|:        ::||      :.:|||..
Human  2511 SQDDGLIN-----------------------RAKA--------VKQF------EESRGRTS---- 2534

  Fly   414 LHILSVKHFWHGIHRTVLARLSHA--PATPTYLYRFDVDSPHFNHFRQ----------VMC---- 462
                |...|:..:..::....|.|  .|..|:.|..:..:..:..|.:          ::|
Human  2535 ----SKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIID 2595

  Fly   463 -----GKHVRG---VSHADD----------------LSYLFYHILANKVDKSSMEYQTIQ-RLVG 502
                 .|..||   :.||.:                |...||.....:.   |:|.:::. :::.
Human  2596 MASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQF---SLEEKSLSLKIMQ 2657

  Fly   503 MWVAFARNDNPNCP 516
            .:..|.|:.|||.|
Human  2658 YFSHFIRSGNPNYP 2671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	130/534 (24%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	40/139 (29%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		130/534 (24%)
		COesterase	2197..2718	CDD:395084	130/534 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930