DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and LOC688542

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	XP_038954018.1	Gene:	LOC688542 / 688542	RGDID:	1587637	Length:	559	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	168/572 - (29%)
Similarity:	252/572 - (44%)	Gaps:	118/572 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TRDGQVRG---HRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQ 98
            |..|||||   |.:.|..|   ...|.|||||:||||.|||..|:.|.||.||||.|...|..:|
  Rat    36 THTGQVRGSLVHVKDTDID---VHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDATSHPAMCLQ 97

  Fly    99 K------------HFVLSIVEGSEDCLYLNVYS-KRLRSDKPLPVIVWIYGGGFQFGEAGRDFYS 150
            .            ..:|..:..||||||||:|: ........|||:|||:||....|.|  ..|.
  Rat    98 NDNMMGSEDMKIMKLILPPISMSEDCLYLNIYAPTHAHEGSNLPVMVWIHGGALTVGMA--SMYD 160

  Fly   151 PDYF-MQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNIT 214
            .... ..:||||||..||:|.|||.|..|.  ...||.|..|||.||||:.||||.|.|:|..:|
  Rat   161 GSMLAATEDVVVVTIQYRLGVLGFFSTGDE--HARGNWGYLDQVAALRWVQQNIAHFGGNPNRVT 223

  Fly   215 VMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAYRLACQLGYSGSENEKEV 279
            :.|||||..||.:.:.:..::||||.|||:||.:........|....||:...|....:.:.:.:
  Rat   224 IFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVVVLPDLISRSSEMVYRIVANLSGCAAVDSETL 288

  Fly   280 FRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPL 344
            .:.|:....:|:.         :..:.:.:.|  .||:...     ||:..:|:|..|..:.:|.
  Rat   289 MQCLRGKSEAEIL---------DINKVFKIIP--AVVDGEF-----LPKHPQELLASANFHRVPS 337

  Fly   345 ILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIP---------REIREKSTQSHLK----------- 389
            |:|.|:.|                  :..::|         .||..|:..:.||
  Rat   338 IIGINNDE------------------YGWILPMIFDSAQKIEEITRKTLPTVLKSTALKMMLPPE 384

  Fly   390 --DLLRQFKVDNFDDATRGRMEFNE-------CLHILSVKHFWHGIHRTVLARLSHAPATPTYLY 445
              |||.:..:.:.:|....:.:|.|       .:..|.|.||          :.|||   |.|.|
  Rat   385 CGDLLMEEYMGDTEDPKTLQAQFREMMGDFMFVIPALQVAHF----------QRSHA---PVYFY 436

  Fly   446 RFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILAN-KVDKSSMEYQTIQRLVGMWVAFAR 509
            .|.    |.:.|.:.:...||: ..|.|::..:|.:::.: |...:..|....::::..|..|||
  Rat   437 EFQ----HRSSFFKDVKPPHVK-ADHGDEVFLVFGYLVGDIKFPHTEEEELLSRKIMKYWANFAR 496

  Fly   510 NDNPNCPQIGPTTWEALDEKGPQMCLNI----GKQLEFIVLPESKQNRIWDR 557
            :.|||..  |...|..:|.....:.|:|    |:.|      ::::.:.|.:
  Rat   497 HGNPNSE--GLPHWPVMDHDDQYLQLDIQPSVGRAL------KARRLKFWTK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	166/554 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	51/117 (44%)
LOC688542	XP_038954018.1	COesterase	30..538	CDD:395084	167/568 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810