DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and LOC679149

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	172/584 - (29%)
Similarity:	256/584 - (43%)	Gaps:	114/584 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVR 87
            ||.:...:.:.:..|..|||||........:.....|.|||||:||||.|||..|:.|.||.|||
  Rat    24 VQGQHSPESSPIRNTHIGQVRGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVR 88

  Fly    88 DCTYPRAKPMQKHFVLSIVEG-------------SEDCLYLNVYS-KRLRSDKPLPVIVWIYGGG 138
            |.|...|..:|...|:: .||             ||||||||:|: ........|||:|||:|||
  Rat    89 DGTSQPAMCLQNLDVIN-AEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAHEGSNLPVMVWIHGGG 152

  Fly   139 FQFGEAGRDFYSPDYF-MQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQN 202
            ...|.|  ..|..... :.:|:||||..||:|.|||.|..|.  ...||.|..|||.||||:.||
  Rat   153 LMTGMA--SMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDE--HARGNWGYLDQVAALRWVQQN 213

  Fly   203 IAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEW-ANEPSGRWAYRLAC 266
            ||.|.|:|..:|:.|||||...|...:.:..::||||.|||:||.....: ..:.|..::..:|.
  Rat   214 IAHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPYLIADTSEMFSTMVAK 278

  Fly   267 QLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHR 331
            ..|....::|..|.....|:.|..:|   |..|.|              :.|.:.....|||..:
  Rat   279 VSGCEAMDSEALVHCLRAKSEAEILA---INKVVQ--------------MVPAVVDGEFLPRHPK 326

  Fly   332 EMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLK------- 389
            |:|.......:|.|:|.|:.|    |..|:   ..::...:::  :|:..::.|:.||
  Rat   327 ELLASEDFRPVPSIIGVNNDE----YGWTI---PLVMGTTQMI--KELSRENLQAILKKTTAQLM 382

  Fly   390 ------DLLRQFKVDNFDDATRGRMEFNECLH-------ILSVKHFWHGIHRTVLARLSHAPATP 441
                  |||.:..:.:.:|....:.:|.|.:.       .|.|.||          :.|||   |
  Rat   383 LPLECSDLLMEEYMGDIEDPKTLQAQFTELMEDFMFVIPALQVAHF----------QCSHA---P 434

  Fly   442 TYLYRF--------DVDSPHFNHFRQVMCGKHVRGVSHADDLSYLF-YHILANKVDKSSMEYQTI 497
            .|.|.|        |:..||..             ..|.|::.::| |.....|.|.:..|....
  Rat   435 VYFYEFQHQITFLKDIRPPHVK-------------ADHGDEIPFVFGYFFWDMKTDFTEEEKLLS 486

  Fly   498 QRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLN----IGKQLEFIVLPESKQNRIWDR 557
            :|::..|..|||:.|||..  |.:.|..:|.....:.|:    :|:.|      ::::.:.|.:
  Rat   487 RRMMKYWANFARHGNPNSE--GLSYWPVMDHDQQYLQLDTQPAVGRAL------KARRLQFWTK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	168/561 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	50/117 (43%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	169/573 (29%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	48/106 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640