Protein Alignment alpha-Est1 and NLGN2

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 170/597 - (28%)
• Similarity: 261/597 - (43%)
• Gaps: 118/597 - (19%)

  Fly    27 LGTKQTKVVCTRDGQVRGHRRRTLYDEEM--YFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC 89
            ||.::..||.|..|:|||.||. |.:|.:  ...|.|:|:|.||:|..||:.|:.|..|.|||:.
Human    36 LGEERFPVVNTAYGRVRGVRRE-LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNA 99

  Fly    90 -TYPRAKPMQKHFVLSIV------------------EGSEDCLYLNVY---------SKR----- 121
             |.|.|.|...|..|..:                  ..||||||||:|         .||
Human   100 TTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATL 164

  Fly   122 ------LRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRD 180
                  :|.....||:::::||.:..| .|..|.........:|:|.|.|||:|.|||||..|:
Human   165 NPPDTDIRDPGKKPVMLFLHGGSYMEG-TGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQ- 227

  Fly   181 LDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQS 245
             ...||.||.||:.||||:|:|||.|.|||:.||:.|..|||:.|:.|:.:..:.|||.|||.||
Human   228 -AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQS 291

  Fly   246 GSMFCEWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVL 309
            |:....|: |....::...||.::| ...|:..|....|::.|:.|:..|.:     :..|.::
Human   292 GTAISSWSVNYQPLKYTRLLAAKVG-CDREDSAEAVECLRRKPSRELVDQDV-----QPARYHI- 349

  Fly   310 FPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHM-LSAFEV 373
             .|.|||:     ..|:|.....::.:....:..:::|.|..|||...:.:...|:.: .|||:.
Human   350 -AFGPVVD-----GDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDF 408

  Fly   374 LIPREIREKSTQSHLKDLLRQ---FKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLS 435
            .:...:.........||:||:   |...::.|...|.|. .:.|..|...|.|  :...|.....
Human   409 TVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMR-RKTLLALFTDHQW--VAPAVATAKL 470

  Fly   436 HAP-ATPTYLYRFDVDSPHFNHFRQVMCGKHVR----GVSHADDLSYLFYHILANKVD------- 488
            ||. .:|.|.|.|      ::|     |....|    ..:|.|:|.|:|...:....|
Human   471 HADYQSPVYFYTF------YHH-----CQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFS 524

  Fly   489 KSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNR 553
            |:.:....:  ::..|..||:..:||.|                    :.:..:||   .:|.||
Human   525 KNDVMLSAV--VMTYWTNFAKTGDPNQP--------------------VPQDTKFI---HTKPNR 564

  Fly   554 ----IWDRLYDK 561
                :|.:...|
Human   565 FEEVVWSKFNSK 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	162/570 (28%)
		Aes	<117..>233	CDD:223730	50/135 (37%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	168/592 (28%)
		Aes	<170..>268	CDD:223730	43/100 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740