Protein Alignment alpha-Est1 and ces2b

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: XP_021326380.1
• Gene: ces2b / 561967
• ZFINID: ZDB-GENE-041014-96
• Length: 1611
• Species: Danio rerio
• Alignment Length: 603
• Identity: 182/603 - (30%)
• Similarity: 258/603 - (42%)
• Gaps: 108/603 - (17%)

  Fly     5 VGVGDLLKMGTKLIGH-------KIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGI 62
            :|:|...|......|:       |:.|.....|:..||.|:.|.:||........:.:..::.|:
Zfish  1046 LGIGLEQKSSKNFKGNHFHFMIEKLPQIIKEWKEGPVVETKLGSLRGAFLTVKGKDTIVNSYLGV 1110

  Fly    63 PFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPMQKHFVLS----------IVEGSEDCLYLN 116
            |||:||||.||...||....|.||||.| .||....::...::          :.|.||||||||
Zfish  1111 PFAKPPVGPLRLARPQAAEKWQGVRDATKQPRMCLQERQMTVTELEFLSMDVEVPEVSEDCLYLN 1175

  Fly   117 VYS--KRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYF-MQQDVVVVTFNYRVGALGFLSLAD 178
            :|:  |..:.||.|||:|||:|||...|.|  ..|..... ..||||||...||:|.|||||..|
Zfish  1176 IYTPVKPGQGDKKLPVMVWIHGGGLSLGSA--SMYDGSVLAAYQDVVVVLIQYRLGLLGFLSTGD 1238

  Fly   179 RDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIM 243
            .  ..|||.|..|||.||:|:.:||..|.|||.::|:.|||||..||..|:.:....||||:||.
Zfish  1239 E--HAPGNYGFLDQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSTLILSPLASGLFHRAIA 1301

  Fly   244 QSGSMFCEWAN----EPSGRWAYRLACQLGYSGSENEK--EVFRYLQKAPASEMAAQGITLVSQE 302
            :||:.|  |..    :|..| |...|.|.....|.:.|  :...:..:..|.|.|
Zfish  1302 ESGTAF--WDGLVMADPFQR-AQTAAKQCNCDSSSSAKIVDCIMHWSEEEALECA---------- 1353

  Fly   303 ERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFE-GLFSYQSTLHDE-- 364
              :::.:..|:..|:.|.     ||:...|::.:...:.:|||.|.|:.| |....:..|..|
Zfish  1354 --KKFQMMHFSVAVDSYF-----LPKPIEEIVEKQEFSKVPLINGINNDEFGFLLAEYFLGPEWM 1411

  Fly   365 -----EHMLSAFEVLIP----REIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVK 420
                 |.:..|..:..|    |.|.:...:.:|.|.....::........|.:.||
Zfish  1412 NGLKREQIAEALTLTYPDPKDRWIIDLVAKEYLGDTHDPIEIREVYREMMGDVLFN--------- 1467

  Fly   421 HFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILAN 485
                 |....||:.......|.|||...    |...|.|......| ||.|||||    |.|...
Zfish  1468 -----IPALQLAKHHSGTGAPVYLYELQ----HPPSFLQKKRPSFV-GVDHADDL----YFIQGT 1518

  Fly   486 KVDKSSM---------EYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNI---- 537
            ...|:.:         |.:..:.::..|..||...:||.|  |.|.|...:.:...:.:.:
Zfish  1519 CFAKAHLRISAPFTEEENELCRTVMAYWGNFAHTGSPNGP--GLTHWPEYENENEYLAIGLQQKP 1581

  Fly   538 GKQL-----EFI--VLPE 548
            ||.|     ||:  .|||
Zfish  1582 GKNLKHKHYEFMTKTLPE 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	175/570 (31%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:395084
		COesterase	553..1065	CDD:395084	4/18 (22%)
		COesterase	1079..1592	CDD:395084	170/561 (30%)