DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and NLGN3

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	672	Identity:	185/672 - (27%)
Similarity:	279/672 - (41%)	Gaps:	141/672 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEIRVGVGDLLKMGTKLIGHKI--------VQYRLGTK-QTKVVCTRDGQVRGHR----RRTLYD 52
            |.:|:|...|.......:|..:        :..|..|: ....|.|..|::||.|    ...|..
Human     1 MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGP 65

  Fly    53 EEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPMQKHFV-------------L 103
            .:.|.   |:|:|.||:||.||..|:||..|.|:|:.| :|...|...|..             |
Human    66 VDQYL---GVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANL 127

  Fly   104 SIV-----EGSEDCLYLNVY-----SKRLRSD---KP---------------------------- 127
            .||     |.:|||||||||     .||:..:   ||
Human   128 DIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDE 192

  Fly   128 -------LPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPG 185
                   .||:|:|:||.:..| .|............:|:|:|.|||||.|||||..|:  ...|
Human   193 DIRDSGAKPVMVYIHGGSYMEG-TGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQ--AAKG 254

  Fly   186 NAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFC 250
            |.||.||:.||||:|:|||.|.|||:.|||.|...||:.|..|..:..:.|||.:||:||||...
Human   255 NYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALS 319

  Fly   251 EWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTP 314
            .|| |....::...||.::|.:..:....|....||: |.|:..|.|     :..|.:|.|
Human   320 SWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKS-AKELVEQDI-----QPARYHVAF---- 374

  Fly   315 VVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSA-FEVLIPRE 378
              .|.|..| |:|.....::.:....:..::||.|..|||...:..:..|:.:... |:..:...
Human   375 --GPVIDGD-VIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNF 436

  Fly   379 IREKSTQSHLKDLLRQ-FKVDNFDDATRGRMEF-NECLHILSVKHFWHGIHRTVLARLSHAP-AT 440
            :.........||.||: .|....|.|.|...|. .:.|..|...|.|  :..:|:....||. .:
Human   437 VDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQW--VEPSVVTADLHARYGS 499

  Fly   441 PTYLYRFDVDSPHFNHFRQVMCGKHV-RGVSHADDLSYLFYHILANKVD-------KSSMEYQTI 497
            |||.|.|      ::|.:.:|  |.. ...:|.|::.|:|...:....|       |:.:....:
Human   500 PTYFYAF------YHHCQSLM--KPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAV 556

  Fly   498 QRLVGMWVAFARNDNPNCP-------------QIGPTTWEALDEKGPQMCLNIGKQLEFIVLPES 549
              ::..|..||:..:||.|             :.....|...:.: .|:.|:||  |:..|....
Human   557 --VMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPR-DQLYLHIG--LKPRVRDHY 616

  Fly   550 KQNRI--W----DRLYDKNDLF 565
            :..::  |    ..||:.:|:|
Human   617 RATKVAFWKHLVPHLYNLHDMF 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	172/605 (28%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	54/158 (34%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	174/621 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740