DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and CG10175

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	201/573 - (35%)
Similarity:	300/573 - (52%)	Gaps:	46/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KIVQ--YRLGTKQTKVVCTRD-GQVRGHRRRTLYDEE-MYFAFEGIPFAQPPVGELRFRAPQPPH 81
            ::||  .|...|:.::|.|.. |:|||..::....|. .|::|:|:.:..||.|..||||.:|..
  Fly   139 RVVQEVVRSLRKEREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEK 203

  Fly    82 PWLGVRDCTYPRAKPMQKHFVLSIVEGSEDCLYLNVYSKRLRSD-----KP-LPVIVWIYGGGFQ 140
            ||.|:||.:........|:.:|...:|.||||::||::.::..|     :| |||:||::||||.
  Fly   204 PWSGIRDASREGQSCPHKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFS 268

  Fly   141 FGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQ 205
            ||......|.|||.:.:|:|:||.|||:|.||||:...   |.|||.||||||:||:|:..|||.
  Fly   269 FGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFLTAGP---DAPGNQGLKDQVLALKWVRDNIAA 330

  Fly   206 FNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA-NEPSGRWAYRLACQLG 269
            |.|||..:|:.||||||:||..|:.:.|.:||||:||.||||....|: :..|.:.|.|||..||
  Fly   331 FGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLG 395

  Fly   270 YSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREML 334
            |.|:...:::..:|::.||.::.....|.::.|::|..:..||.||||.|..:|....:.:.|..
  Fly   396 YVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPF 460

  Fly   335 ----------PEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFE----VLIPREIREKSTQ 385
                      .:.:.:|:..:.|.|:.|.:. :...|.....:||..|    .|:|:::  ..|:
  Fly   461 LTQHPSDMYHSQNFNSDVAYMTGYNTHEAML-FIRRLRKNPQLLSIIENDFGRLVPQDL--NVTE 522

  Fly   386 SHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAP--ATPTYLYRFD 448
            ||.: :.|:.:.........|....:|.:.:|:...|..||.||  || :||.  ..|.|:|||.
  Fly   523 SHDR-VTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRT--AR-NHAKFGNAPVYMYRFS 583

  Fly   449 VDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILAN-KVDKSSMEYQTIQRLVGMWVAFARNDN 512
            .|.....:.|  |.|....||.|.|:|.|||.....| .:|..|||.|...|:|.||..||:..:
  Fly   584 FDGSLGLYKR--MLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGS 646

  Fly   513 PNCPQIGP---TTWEALDEKGPQMCLN---IGKQLEFIVLPESKQNRIWDRLY 559
            |......|   |.|..:|.......||   |...|.....||.::.|.||.:|
  Fly   647 PTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	191/544 (35%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	60/121 (50%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	193/549 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760