DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ace

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	160/567 - (28%)
Similarity:	250/567 - (44%)	Gaps:	104/567 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQ 98
            ||.|..|.||| |..|:...|:: .:.|||:|:|||.:||||.|.|..||.||.|.|...|..:|
  Fly    44 VVQTSSGPVRG-RSVTVQGREVH-VYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106

  Fly    99 KHFVLSIVEG-------------SEDCLYLNVYS---KRLR-------SDKP------------- 127
            :.:  ....|             ||||||:||::   .|||       .:.|
  Fly   107 ERY--EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHN 169

  Fly   128 ---------LPVIVWIYGGGFQFGEAGRDFYSPDYFMQ-QDVVVVTFNYRVGALGFLSLA----- 177
                     ||:::|||||||..|.|..|.|:.|.... .:|:|.:|.|||||.|||.||
  Fly   170 GNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPS 234

  Fly   178 DRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAI 242
            :...:.|||.||.||.:|:||:..|...|.|:|:.:|:.|||||::||:|.:.:..||||..:.:
  Fly   235 EFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGM 299

  Fly   243 MQSGSMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPA---SEMAAQGITLVSQEER 304
            ||||:|...|::..|.:     |.::|.:...:.......|:..||   |.|.:.....:|.::.
  Fly   300 MQSGTMNAPWSHMTSEK-----AVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQW 359

  Fly   305 RQY---VLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEH 366
            ..|   :.||..|.::     ...||.....::..|...|..:::|....||.:   ..|:|
  Fly   360 NSYSGILSFPSAPTID-----GAFLPADPMTLMKTADLKDYDILMGNVRDEGTY---FLLYD--- 413

  Fly   367 MLSAFE----VLIPRE--------IREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSV 419
            .:..|:    ..:||:        |..|:||:..:.::.|:.....:...:.:.:....:.
  Fly   414 FIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVG---- 474

  Fly   420 KHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILA 484
            .||:..........|:...|:..|.|        |.|...........||.|.|::.|.|...|.
  Fly   475 DHFFTCPTNEYAQALAERGASVHYYY--------FTHRTSTSLWGEWMGVLHGDEIEYFFGQPLN 531

  Fly   485 NKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGP 531
            |.:....:|.:..:|::...:.||:..||  .|.| ..|....::.|
  Fly   532 NSLQYRPVERELGKRMLSAVIEFAKTGNP--AQDG-EEWPNFSKEDP 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	160/567 (28%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	55/153 (36%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	160/567 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740