DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and CG4757

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	169/585 - (28%)
Similarity:	264/585 - (45%)	Gaps:	123/585 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWL-GVRDCTYPRAKPMQ 98
            |.|..|:|||....:..... :.||.||.:|:||:|:|||..|||..||. .:.|.:  ...||.
  Fly    23 VDTELGRVRGANLTSRLGVN-FHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDAS--EDGPMC 84

  Fly    99 KHFVLSIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIYGGGFQ-FGEAGRDFYSPDYFMQQDVVVV 162
            .....::.:.|||||.||||:|.|:..:  ||||:::.|||. |....:....|::||.:|.|:|
  Fly    85 PQPWDNMTDVSEDCLRLNVYTKDLKGRR--PVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLV 147

  Fly   163 TFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHA 227
            :.|||:|:||||:...:  :.||||||||||:|||||.|:|.:|.|||.::|::|.|||:.||..
  Fly   148 SLNYRLGSLGFLATGSK--EAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVAL 210

  Fly   228 LMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRY---LQKAPAS 289
            .|.:..:|||||:.|..|.:        |.|...|:          :|:.::.:.   |.|.| .
  Fly   211 HMLSPMSRGLFHRGICMSAA--------PYGPVKYK----------DNDLQLAKRQAGLLKCP-Q 256

  Fly   290 EMAAQGITLVSQEERRQYV-----LFPF--TPVVEPYITRDCVLPRCHREMLPEAWGND------ 341
            |...:.:..:.::....||     :|.|  .||:.            .|.::.:.:|.:
  Fly   257 ESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLN------------WRIVVEKDFGQERYLIES 309

  Fly   342 ------------LPLILGGNSFEGLFSYQSTLHDE----------EHMLSAFEVLIPREIREKST 384
                        :.||.|...||.|......|.:|          ||..|     |...:.:.||
  Fly   310 PFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYAS-----IALLLEQNST 369

  Fly   385 QSHLKDLLRQFKVDNFDDATRGRMEFNECL----HILSVKHFWHGIHRTVLARLSHAPATPTYLY 445
            ||....  |.|: :.:...:..::|:.:.|    .:||........||.:.....|.|.. |||:
  Fly   370 QSRAAS--RVFR-EKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIY-TYLF 430

  Fly   446 RFD-----VDSPHFNHFRQVMCGKHVRGVSHADDLSYLFY-HILANKVDKSSMEYQTIQRLVGMW 504
            |:.     :.:|.         .:...|..|.|:|.|||: .:|...:.:...|...|:.|..||
  Fly   431 RYKGRYTFLKNPD---------NQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELLTRMW 486

  Fly   505 VAFARNDNP---NCPQIGPTTWEALD--EKGPQMCLNIGKQLE-----FIVLPESKQNRIWDRLY 559
            :.||:..:|   |...:....|...:  :||   .|.||..|.     |.:    .:.:||:.|:
  Fly   487 IEFAQKGDPHNKNDEYLKGLNWPLYNAQDKG---YLEIGNNLTAKSGGFFL----NRYQIWEDLF 544

Fly 560 559
Fly 545 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	164/560 (29%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	55/116 (47%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	166/579 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	76/170 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467395
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800