DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and alpha-Est4

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	230/545 - (42%)
Similarity:	321/545 - (58%)	Gaps:	39/545 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQ 98
            ||.|..|:|||...::||||:.| ||:|||:|.||:|.|||:.|....||.|:|||:.|.:|.:|
  Fly    11 VVQTTHGKVRGILLKSLYDEQFY-AFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ 74

  Fly    99 KHFVLSIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVT 163
            ...:...|||||||||||:..|.|..| |:||:|:|:||.|:.|::.|..:.|||||:::||.::
  Fly    75 VSTLTKEVEGSEDCLYLNISVKTLNGD-PMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYIS 138

  Fly   164 FNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHAL 228
            ..:|:|.||||||.|.||:|||||||||.::|||||..|.|.|||||:.||:.|.|:|:.:|..|
  Fly   139 IGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLL 203

  Fly   229 MTTEQTRGLFHKAIMQSG-SMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKA-PASEM 291
            :.:.|:.||||:||:.:| ||  |....|  :..||||..|||.|...:.:|..:|.|| ||..:
  Fly   204 LASPQSEGLFHRAILLAGFSM--ELNRLP--QMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIV 264

  Fly   292 AAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFS 356
            :|...|.:   |:||....||.|.:|.|.|.:.||.....::....|.|.:|:|||.||.||: |
  Fly   265 SADFFTPL---EKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGM-S 325

  Fly   357 YQSTLHDEEHMLSAF----EVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHIL 417
            ..|.:......|..|    |.::|..:|.:......:. |.|..:.:|.:| .|        |.|
  Fly   326 IFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQ-LGQALIHHFCEA-HG--------HEL 380

  Fly   418 SVKH-----------FWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSH 471
            :|.|           |.|.:.|.:.:||::..| ||||||||.|||.||.:|....||..|||.|
  Fly   381 TVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQA-PTYLYRFDFDSPDFNFYRIRFMGKEQRGVGH 444

  Fly   472 ADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQI-GPTTWEALDEKGPQMCL 535
            .|:|.|:|......|:|||..|:..|:|||.|:|.||...:||.|.. ....|:.:...|.:|.|
  Fly   445 VDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVL 509

  Fly   536 NIGKQLEFIVLPESKQNRIWDRLYD 560
            ||.::|:||..||..:.:.:||||:
  Fly   510 NISEELKFIPQPEMPKLKFFDRLYE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	221/524 (42%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	59/115 (51%)
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	226/538 (42%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	62/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467381
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900