Protein Alignment alpha-Est1 and Ces3a

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 607
• Identity: 177/607 - (29%)
• Similarity: 254/607 - (41%)
• Gaps: 127/607 - (20%)

  Fly    10 LLKMGTKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRF 74
            ||...|.:||.|:.|..:.|..        |:|||.:......:.|...|.||||||.|:|.|||
Mouse    22 LLIFPTTVIGPKVTQPEVDTPL--------GRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRF 78

  Fly    75 RAPQPPHPWLGVRD-------CTYPRAKPMQKHFVLS----IVEGSEDCLYLNVYS-KRLRSDKP 127
            .||.||.||.||||       |.....:.....|.|:    |...|||||.||:|| ..:.:...
Mouse    79 SAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDK 143

  Fly   128 LPVIVWIYGGGFQFGEAGRDFYSPD---YFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGL 189
            .||:|||:||....|.:    .|.|   .....||||||..||:|..||||..|:.:  |||.|.
Mouse   144 RPVMVWIHGGSLLVGSS----TSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHM--PGNRGF 202

  Fly   190 KDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCE--- 251
            .|.|.||||:..|||.|.|||..:|:.|.|||...|.:|:.:..:.||||:||.|||.:..:
Mouse   203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILE 267

  Fly   252 ----WANEPSGRWAYRLACQLGYSGSENEKEVFR-YLQKAPASEMAAQGITLVSQEERRQYVLFP 311
                |:.  :..:|..:||     ||.:..|:.: .|||        :|..|::::.
Mouse   268 DLNAWSE--AQNFANSVAC-----GSASPAELVQCLLQK--------EGKDLITKKN-------- 309

  Fly   312 FTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEG---LFSYQSTLHDEEHMLSAFEV 373
               |...|...|...|:..:::|.......:|.:||..:.|.   |..:.:.|...|| ||..::
Mouse   310 ---VNISYTVNDSFFPQRPQKLLANKQFPTVPYLLGVTNHEFGWLLLKFWNILDKMEH-LSQEDL 370

  Fly   374 L-----------IPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIH 427
            |           :|.||.......:|         ||..|.:..|....|.|..:::.     |.
Mouse   371 LENSRPLLAHMQLPPEIMPTVIDEYL---------DNGSDESATRYALQELLGDITLV-----IP 421

  Fly   428 RTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSM 492
            ..:.::.......|.:||.|......|..|:....     ...|:.:.:::|.....  .|:||:
Mouse   422 TLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKPAWV-----KADHSSENAFVFGGPFL--TDESSL 479

  Fly   493 ---------EYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQ-------- 540
                     |.|....::..|..|||..|||...:.|  |..|::.  :..|.||.:
Mouse   480 LAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPP--WPQLNQL--EQYLEIGLEPRTGVKLK 540

  Fly   541 ---LEF--IVLPESKQNRIWDR 557
               |:|  ..||...|.  |.|
Mouse   541 KGRLQFWTETLPRKIQE--WHR 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	163/569 (29%)
		Aes	<117..>233	CDD:223730	50/119 (42%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	165/576 (29%)
		Aes	75..>245	CDD:223730	74/175 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740