DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ces1b

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	609	Identity:	165/609 - (27%)
Similarity:	244/609 - (40%)	Gaps:	137/609 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPW 83
            ||        :..:.||.|..|::.|........|.....|.|:|||:||:|.|||..|:|..||
Mouse    18 GH--------SPSSPVVDTTQGKILGKYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAEPW 74

  Fly    84 LGVRDCT-YPRAKPM--QKHFVLSIVEG-------------SEDCLYLNVYSKR-LRSDKPLPVI 131
            ..|::.| ||   ||  |....:.::..             ||||||||:||.. |.....|||:
Mouse    75 SFVKNATSYP---PMCSQDAVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVM 136

  Fly   132 VWIYGGGFQFGEAGRDFYSP-DYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMA 195
            |||:|||...|  |...|:. .....::|||||..||:|..|..|..|.  ...||....||:.|
Mouse   137 VWIHGGGLMTG--GASLYNGLALSAHENVVVVTIQYRLGIWGLFSTGDE--HSRGNWAHLDQLAA 197

  Fly   196 LRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMF----------- 249
            |||:..|||.|.|:|.::||.|.|||..||..|:.:...:.|||:||.:|..:.
Mouse   198 LRWVQDNIANFGGNPDSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSVVLENIVITLDLVA 262

  Fly   250 CEWA---------NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERR 305
            |:.:         |:.|.....:...|      :.|.|:.....|...:::.  |.....::..
Mouse   263 CDLSQMIATVSGCNDTSSTAMVQCLRQ------KTENELLEITVKLEVTKVG--GAASAKKDNT- 318

  Fly   306 QYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNS---------------FEG-- 353
                 ..:.|::     ..|||:...|:|.|...:.:|.|:|.|.               .||
Mouse   319 -----SMSTVID-----GVVLPKAPEEILAEKSFSTVPYIVGFNKQEFGWIIPTMLGDLLSEGKM 373

  Fly   354 --------LFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEF 410
                    |..:.|.|:..|.::.|   :|.:.:|.....:..:|||    :|.|.|.
Mouse   374 NEETASLLLRRFHSDLNISESLIPA---VIEKYLRGTDDPAKKRDLL----LDMFSDV------- 424

  Fly   411 NECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGV--SHAD 473
                        :.||...:|:|........||:|.|.. .|.|      :..|..:.|  .|.|
Mouse   425 ------------FFGIPAVLLSRSLRDAGVSTYMYEFRY-RPSF------VSDKRPQTVEGDHGD 470

  Fly   474 DLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIG 538
            :: :..:.|...|...|..|....:.::..|..||||.|||..  |...|...|||  :..|.||
Mouse   471 EI-FSVFGIPLLKEGTSEEETNLSKMVMKFWANFARNGNPNGE--GLPHWPEYDEK--EGYLQIG 530

  Fly   539 KQLEFIVLPESKQNRIWDRLYDKN 562
            ...:.....::::...|..|..||
Mouse   531 ATTQQAQRLKAEEVAFWTELLAKN 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	159/577 (28%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	49/117 (42%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	160/599 (27%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	49/121 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650