DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and CG10339

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_611881.1	Gene:	CG10339 / 37854	FlyBaseID:	FBgn0034972	Length:	603	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	144/581 - (24%)
Similarity:	226/581 - (38%)	Gaps:	148/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 AFEGIPFA-----QPPVGELRFRAPQPPHPWLGVRDCT------YPRAKP---MQKHFVLSIVEG 108
            |:.||.:|     |||..||.        ||.|:.:.|      :..|.|   .:...:|.|::.
  Fly    57 AYLGIRYAHARRFQPPDIELT--------PWKGIFNATVFQPDCWQNAMPSVGKETEQILKIIQS 113

  Fly   109 -----------SEDCLYLNVY-SKRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVV 161
                       .|:||||||: ...|.......|:|||:.|.|..|... |........:|.|:|
  Fly   114 DSSAQDAERKYEENCLYLNVFVPDGLPEINGYAVVVWIHSGDFSTGSPA-DVEPFQLVFKQKVIV 177

  Fly   162 VTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVH 226
            |||:||:...||.:..|.  :..||.||.||..||.|:.:||..|.||...||:||..|||.||.
  Fly   178 VTFSYRLNIFGFFTTDDG--EAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVA 240

  Fly   227 ALMTT-EQTRGLFHKAIMQSGSMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASE 290
            ..||: |.::|.|||||:.||:..      .:.:..|.      |.||.::........:.|.|
  Fly   241 LHMTSGEWSKGGFHKAIIMSGNPL------STVKMPYE------YEGSLDQVSSTFACPRRPTS- 292

  Fly   291 MAAQGITLVSQEERRQYVLFP---FTPVVE--------PYITRDCVLPRC-------HREMLPEA 337
            |..|.:..:  :.:|.....|   :.|||:        |:|...   |..       ||
  Fly   293 MFIQCLKRI--DAKRLSENLPQVSWGPVVDFGLSNTSYPFIENQ---PEILFKKGSYHR------ 346

  Fly   338 WGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKD--------LLRQ 394
                :|:|:|             :.|.|.:|:.|:..:..:|.....:....|        |:|.
  Fly   347 ----VPVIIG-------------VTDMEEVLTLFKDNLDTDISPSDLEGFYTDIAVTDMHKLVRN 394

  Fly   395 FK----------VDNF---DDATRGRMEFNECLHILS--VKHFWHGIHRTVLARLSHAPATPTYL 444
            ::          ..||   :|:.....:.|:  ||:|  .:.|:....:|....:|:.....:||
  Fly   395 YEWCSNYELISDAINFMYANDSDTDAKKANK--HIISAHTEKFYITPMQTFADLISNDSQVYSYL 457

  Fly   445 YRFD-----VDSPHF----NHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRL 500
            :|..     .|.|.:    .:|.|:.    |.|..:           :.|.||..|.:.:....:
  Fly   458 FRMRPRSVLQDLPSWISVPKYFDQIF----VWGNPY-----------MTNSVDWKSTDKKIADII 507

  Fly   501 VGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYDK 561
            :.:|..||:..||....: ...|.|:......:.| |.:......|..:::...|..||.|
  Fly   508 MTLWANFAKTSNPTKSNV-YVKWNAMTPNNDSVLL-IDESFNTDNLLNNQRINFWRSLYPK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	139/559 (25%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	46/117 (39%)
CG10339	NP_611881.1	COesterase	30..560	CDD:278561	140/573 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	4	3.810