DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and gas

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	340/566 - (60%)
Similarity:	435/566 - (76%)	Gaps:	1/566 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEIRVGVGDLLKMGTKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFA 65
            |::||...|.||:|.|:||||:|||:|||.|||.:.|:.||::|.:||||||.|.|::|||||||
  Fly     1 MDLRVSFSDKLKLGAKIIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFA 65

  Fly    66 QPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQKHFVLSIVEGSEDCLYLNVYSKRLRSDKPLPV 130
            |||||||||||||||..|.|||||||.|.||||::.:.:..||||||||||||:|||.|.|||||
  Fly    66 QPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRNSITNAAEGSEDCLYLNVYAKRLESPKPLPV 130

  Fly   131 IVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMA 195
            :|||:|||||.|.|.|:.|.|||||:.|:::||.|||||.||||||.|::|.:|||||||||:.|
  Fly   131 MVWIFGGGFQVGGASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQA 195

  Fly   196 LRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRW 260
            |||:.:|||.|||||::|||.|||||.||.|.||.|||.|||||:||:||||..|.||.:|..:|
  Fly   196 LRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKW 260

  Fly   261 AYRLACQLGYSGS-ENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDC 324
            ..||..:|||:|: |:|||:..:.|:.|||::|....::|:|||:|.|.:..|.||:|||:..||
  Fly   261 PQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDC 325

  Fly   325 VLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLK 389
            |:|:..:|.|..||||.:|:|:||.||||||||::||.|..:||||||.:||:::|:...:..|.
  Fly   326 VIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEELA 390

  Fly   390 DLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHF 454
            :::|:.|...|||..|..||..|||||||:|:|||.||||:||||::|...||||||||:|||||
  Fly   391 EMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHF 455

  Fly   455 NHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIG 519
            ||:|.:.|||.||||.||||:||:||.||::|:||:|.||:||:||||||.:||...:|||..|.
  Fly   456 NHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIA 520

  Fly   520 PTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYDKNDLF 565
            |..|:.|...|.:.||||...||||.||||||..:||..|.:..|:
  Fly   521 PVKWDPLRPGGVENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	310/513 (60%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	79/115 (69%)
gas	NP_611678.1	COesterase	28..534	CDD:278561	306/505 (61%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	72/104 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467342
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	12	11.810