DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Jhe

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	180/587 - (30%)
Similarity:	277/587 - (47%)	Gaps:	86/587 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLKMGTKLIGHKIVQYRLGTKQTKVVCTRD-GQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELR 73
            ||.:|..|.|.......|.|.....||... |.::|...:. |..|.:.||.|||:|.||:|:||
  Fly     9 LLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQG-YQSERFEAFMGIPYALPPIGDLR 72

  Fly    74 FRAPQPPHPWLGVRDCTYPRAKPMQKHFVL--SIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIYG 136
            |..|:.....||:.|.:.|:...:||:::|  .:|.|.|||||||||...:|. ..|||:|:|:|
  Fly    73 FSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIRK-SALPVMVYIHG 136

  Fly   137 GGFQFGEAGRDFYSPDYFMQQ-DVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWIS 200
            |||..|.||.....|:|||.. :|::||..||:|..||||  .:|..:.||.|||||.:||||:.
  Fly   137 GGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLS--TQDAVMSGNFGLKDQNLALRWVQ 199

  Fly   201 QNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGS----------------MF 249
            :||..|.||||.:|:.|:|||..:.|..:.:.::.||||:.|..||:                :.
  Fly   200 RNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLL 264

  Fly   250 CEWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEM--AAQGITLVSQEERRQYVLFPF 312
            .|:|:.|..|             :.:..::.:.|::..|:::  |..|:.....:.     :..|
  Fly   265 AEFADVPDAR-------------NLSTVKLTKALRRINATKLLNAGDGLKYWDVDH-----MTNF 311

  Fly   313 TPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEE------------ 365
            .||||..:..|..|.....:||.:.....:||:||....||.....:.|.:|.
  Fly   312 RPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDEL 376

  Fly   366 -HMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNEC-----LHILSVKHFWH 424
             ..|..|.....::.|||     :.|||.:...       :|:.|.||.     ::::|.:.|..
  Fly   377 LQELLEFPASFSQDRREK-----MMDLLVEVYF-------QGQHEVNELTVQGFMNLISDRGFKQ 429

  Fly   425 GIHRTVLARLSHAPATPTYLYRFDVDSP--HFNHFRQV-MCGKHVRGVSHADDLSYLFYH-ILAN 485
            .::.|:...:.|.| .|.|||.|:...|  :.:.:... :.||:  ||.|.|||.|||.. :|..
  Fly   430 PLYNTIHKNVCHTP-NPVYLYSFNYQGPLSYASAYTSANVTGKY--GVVHCDDLLYLFRSPLLFP 491

  Fly   486 KVDKSSMEYQTIQRLVGMWVAFARNDNP-NCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPES 549
            ...::|.|.:.|...|..:|.||:...| |...:.|.:.|.|..:...:|    ...||...|::
  Fly   492 DFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGIC----DYHEFANAPDA 552

  Fly   550 KQ 551
            .|
  Fly   553 YQ 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	170/557 (31%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	54/116 (47%)
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	163/523 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440409
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800