DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and CG12869

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	143/563 - (25%)
Similarity:	218/563 - (38%)	Gaps:	158/563 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 FAFEGIPFAQPPVGELRFRAP----------------QPPHPWLG------VRDCTYPRAKPMQK 99
            :||.|||:||.|:.|||| ||                ||..|.|.      ..|.:.||:
  Fly    53 YAFLGIPYAQAPINELRF-APAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRS----- 111

  Fly   100 HFVLSIVEGSEDCLYLNVYSKR--LRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVV 162
                  |...|||||||:::..  :|..| ||::|.:.|..|.:..........| ...:.:|||
  Fly   112 ------VSTDEDCLYLNIWTPESGMRYGK-LPIVVIVTGEEFAYDWPRNRINGLD-LAGEGIVVV 168

  Fly   163 TFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHA 227
            :..||....|:|||.::..:||||.||.|..||||||.:|...|.|:|.:||::|..:|.|.:..
  Fly   169 SVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLAL 233

  Fly   228 LMTTEQTRGLFHKAIMQSGSMF-------CEWANEPSGRWAYRLACQ---------LGYSGSENE 276
            :.|.|.:..:....:|..|.:.       .:|..|.......:|.||         :|....::.
  Fly   234 VATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSR 298

  Fly   277 KEVFR-----YLQKAPASEMAA---QGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREM 333
            :::.|     |.....:|::..   :|:.|   |:|                .|:..||
  Fly   299 EDLLRAYESVYNHGNGSSQLGVILPEGLPL---EQR----------------LRNKTLP------ 338

  Fly   334 LPEAWGNDLPLILGGNSFEGLF--SY--------QSTLHDEEHMLSAFEVLIPREIR-------E 381
                     |::||..|.||.|  .|        |..||...:     ..|:|..:|       |
  Fly   339 ---------PVLLGITSNEGAFLQDYWLDVAREGQVALHKYIN-----HTLLPNVMRALESVGEE 389

  Fly   382 KSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAP-------- 438
            .|||      |...:...|:....|            |.|...|:.|.:...|...|
  Fly   390 SSTQ------LAAIRWRYFNGKGEG------------VSHLLAGMQRLLSESLYELPYSRILELL 436

  Fly   439 -ATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDK---SSMEYQTIQR 499
             .|.:|.|.||.........|:.:.|    |.||:.||..|....|..::.:   |..|.|..::
  Fly   437 NGTTSYAYVFDHSHSMDMRGRRNLFG----GASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRK 497

  Fly   500 LVGMWVAFARNDNPNCPQI--GPTTWEALDEKGPQMCLNIGKQ 540
            :.|.:..|.:|.||...:|  |   |...:::.| ...::|:|
  Fly   498 IRGAFANFIKNGNPTPGRIYDG---WLPYNKENP-FVYSLGEQ 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	143/563 (25%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	40/117 (34%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	143/563 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810