DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and CG3841

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	171/575 - (29%)
Similarity:	262/575 - (45%)	Gaps:	133/575 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPW-----LGVRD---CTYPRAKP 96
            |:::|...::..::.:| ||.||.:||.|||:|||..|.|...|     ....|   |..|.
  Fly    36 GRIQGDTMQSFGNKTIY-AFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQPG--- 96

  Fly    97 MQKHFVLSIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIYGGGFQFGEAGRDFY--SPDYFMQQDV 159
                 |:|::  |||||.:||::|.. .|| .||:|:|:||....| :|...|  .|.|.:.|||
  Fly    97 -----VVSLM--SEDCLKINVFTKSF-EDK-FPVMVYIHGGANVLG-SGHSSYEAGPQYLLDQDV 151

  Fly   160 VVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAAS 224
            |.|.||||:|||||||  ....:..||.|..||||||.|:..:|:.|.|||:.:|::|.|||:.:
  Fly   152 VFVAFNYRLGALGFLS--TNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMA 214

  Fly   225 VHALMTTEQTRGLFHKAIMQSGS---------MFCEWANEPSGRWAYRLACQLG---YSGSENEK 277
            |...:.:..:.||||:||:.|||         :|          |..:||.:||   |    :..
  Fly   215 VSLHLASPLSAGLFHRAILMSGSATNHFDIDNLF----------WTRKLARELGCPMY----DPT 265

  Fly   278 EVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCH-REMLPEAWGND 341
            :|...|:    :|...:.:.:....|..|.|...:...::.:...:      | .|::.|...|.
  Fly   266 DVVECLR----NETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHN------HPTELIKEGNFNK 320

  Fly   342 LPLILGGNSFEGLFSYQSTLH-DEEHMLSAF---------EVLIPR---EIREKSTQSHLKDLLR 393
            :||::...:.|  |.|.:.:| :.:|:|..|         |:.:.|   :|.||....:|.|...
  Fly   321 VPLLISFTANE--FDYNANVHLENQHLLHDFASNFVDYAPELFLYRHDAQIGEKLKDFYLGDNTT 383

  Fly   394 QFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTV-LARLSHAPATPTYLYRFD------VDS 451
            :...:|.::       |.:   |.|..:..||:||.| ||  ||  .||.|..|.|      :.:
  Fly   384 EINSENIEN-------FGQ---IFSDAYIGHGVHRLVQLA--SH--FTPVYYTRMDYVGDQSLSA 434

  Fly   452 PHFNHFRQVMCGKHVRGVSHADDLSYL---FYH---ILANKVDKSSMEYQTIQRLVGMWVAFARN 510
            |.....:.|       ||.|||||.|:   :::   :.||..|...||     ||...:..||:.
  Fly   435 PLNGENKPV-------GVGHADDLHYVLPGYWYGPLMAANDSDVFMME-----RLTSWFTHFAKT 487

  Fly   511 DNP-NCPQIGPTTWEALDEKGPQMCLN-----IGKQLEFIVLPESKQNRIWDRLY 559
            ..| |...|    |...:....:|..|     :|..      ..|.:..:||:|:
  Fly   488 GTPLNSTDI----WPPCNSTVLKMLYNGVVTQVGSP------GYSNRYAVWDKLF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	167/555 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	52/117 (44%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	168/569 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	56/122 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467396
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890