DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and CG9287

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	149/577 - (25%)
Similarity:	230/577 - (39%)	Gaps:	146/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIGHKIVQYRLGTKQ------TKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFR 75
            |:...:|:.|:..:|      |.|.....|.::|....|.:.:.....|..:.:|:||.|..||:
  Fly    13 LVLQSVVESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFK 77

  Fly    76 APQPPHPWLGVRDCT-----YPRAKPMQKHFVLSIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIY 135
            ||:|..||..|.|.|     .|....|.....|..|...||||.:.:.:..:.|  .|||:|:|:
  Fly    78 APRPIEPWEDVMDATAEKIGCPSVVSMDSLRRLDDVLDVEDCLTMTITTPNVTS--RLPVLVYIH 140

  Fly   136 GGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWIS 200
            |.  ...|.......|||.:::|||:||..||:|..||||  .:..::|||||..|..:||:::.
  Fly   141 GE--YLYEGSNSEAPPDYLLEKDVVLVTPQYRLGPFGFLS--TKTDEIPGNAGFLDIFLALQFVK 201

  Fly   201 QNIAQFNGDPQNITVMGESAGAASVHAL-MTTEQTRGLFHKAIMQSGS----MFCEWANEPSGRW 260
            ..|..|.|||..:||.|:..|||..|.| ::....|||||:.|..|||    :|.|   |...:.
  Fly   202 HFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLE---EDPRKH 263

  Fly   261 AYRLA----CQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVL-------FPFTP 314
            |..:|    |::     ...:::...|.:..|.|:    :|...:....:..|       ..||
  Fly   264 AQEIAKKADCKM-----VTVRDLNTCLMELTALEL----LTAFMEHALEKSDLGIGHTGGIQFT- 318

  Fly   315 VVEPYITRDCVLPRCHREMLPEAWGNDLPLILGG---------------NSFEG--------LFS 356
            :..|    ..|||:...:::.|.  |.....:||               |.|||        .::
  Fly   319 IGGP----SGVLPKHPYDLMLET--NFSYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYN 377

  Fly   357 Y-----QSTLHDEEHML-----------------SAFEVLIPREIREKSTQSHLKDLLRQFKVDN 399
            |     :.|:..::.||                 ..|:.||||.|....|.:|...:|....::|
  Fly   378 YIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLPVLLALNMNN 442

  Fly   400 FDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQV---- 460
                                               .|.|.. |:||.||. :..||.::::
  Fly   443 -----------------------------------KHNPDN-TFLYSFDY-AGEFNRYKEMDEET 470

  Fly   461 -MCGKHVRGVSHADDLSYLF---YHILANKVDKSSMEYQTIQRLVGMWVAFARNDNP 513
             :......|||..|:..|||   .|:........||.:    |:|.:|..|..:.||
  Fly   471 NLQSPFKAGVSLTDEALYLFPYPEHVTRLSRPDQSMAH----RMVELWTNFVISGNP 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	146/566 (26%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	44/116 (38%)
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	145/559 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467457
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900