DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Glt

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	150/547 - (27%)
Similarity:	236/547 - (43%)	Gaps:	115/547 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVR----------DCT-YPRAK 95
            :.||  :|:.:..:. ||.||.:.....|..||:|.||    :|.:          :|. :|...
  Fly    73 ISGH--KTIANRPVN-AFLGIRYGTVGGGLARFQAAQP----IGYQGRVNATVQSPNCAQFPELD 130

  Fly    96 PMQKHFVLSIVEGS--EDCLYLNVYSKRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQD 158
            .::    ||...|.  :|||.|::|:.  .....|||:|:::|.  ...:.|.:...|||.:::|
  Fly   131 RLR----LSESRGENVDDCLTLDIYAP--EGANQLPVLVFVHGE--MLFDGGSEEAQPDYVLEKD 187

  Fly   159 VVVVTFNYRVGALGFLS-LADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGA 222
            |::|:.|||:...|||| |.|   ::|||..|.|..:||.|:.:|:..|.|:...:|::|::.||
  Fly   188 VLLVSINYRLAPFGFLSALTD---ELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGA 249

  Fly   223 ASVHALMTTEQTRGLFHKAIMQSGSMFCEWA--NEPSGRWA--YRLA-C---QLGYSGSENEKEV 279
            ...|||..:.:...||.:.|:|||:....:.  |:|....:  .||| |   .:..| ::..|.:
  Fly   250 TLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPS-AQGLKPL 313

  Fly   280 FRYLQKAPASEMAAQGITLVSQEERRQYV-LFPFTPVV-EPYITRDCVLPRCHREMLPEAWGNDL 342
            :..|.:.|.|::.|....|:.|.|..... |..|..|| :|.    ..|| .|...|.......|
  Fly   314 YDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPL----GFLP-SHPASLATNSSLAL 373

  Fly   343 PLILGGNS----------FEGLFSYQS-------------TLHDEEHML----SAFEVLIPREIR 380
            |:|:|...          ::.|...||             |....||.|    :..|:..|.:.:
  Fly   374 PMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQ 438

  Fly   381 EKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLY 445
            ..|.|:....||   ::.|:            .|:...|.:.....:|:|          |.|||
  Fly   439 TASLQTVAPGLL---ELSNY------------ILYRAPVINSISQSYRSV----------PAYLY 478

  Fly   446 RFDVDSPH--FNHFRQVMCGKHVRGV--SHADDLSYLF-YHILANKVDKSSMEYQTIQRLVGMWV 505
            .||....|  |.|....:    ..||  |.:||..||| |...|:::  :.::....:.||.|||
  Fly   479 TFDYRGEHHRFGHLSNPL----PFGVDASLSDDSVYLFPYPPEASRL--NPLDRSLSRALVTMWV 537

  Fly   506 AFARNDNPNCPQIGPTTW-EALDEKGP 531
            .||....|| |..|  .| :|..|.||
  Fly   538 NFATTGVPN-PSSG--VWPQATSEYGP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	150/547 (27%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	40/116 (34%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	150/547 (27%)
		Aes	<146..345	CDD:223730	63/206 (31%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467429
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950