DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ces1e

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_113753.2	Gene:	Ces1e / 29225	RGDID:	621508	Length:	561	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	168/564 - (29%)
Similarity:	247/564 - (43%)	Gaps:	79/564 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YP---RA 94
            ||.|..|:|.|.........:....|.|:|||:||:|.|||..|||..||..|::.| ||   ..
  Rat    25 VVDTLQGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQ 89

  Fly    95 KPMQKHFVLSI---------VEGSEDCLYLNVY-----SKRLRSDKPLPVIVWIYGGGFQFGEAG 145
            .|:....|..:         ::.||||||||:|     :||.|    |||:|||:|||...|.|.
  Rat    90 DPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKRDR----LPVMVWIHGGGLVLGGAS 150

  Fly   146 RDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDP 210
             .:........::||||...||:|..||.|..|.  ...||.|..|||.||.|:..||..|.|||
  Rat   151 -TYDGLALSTHENVVVVVIQYRLGIWGFFSTGDE--HSRGNWGHLDQVAALHWVQDNIDNFGGDP 212

  Fly   211 QNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSG-SMFCEWANEPSGRWAYRLACQLGYSGSE 274
            .::|:.|||||..||..|:.:...:.||||||.:|| ::......:.:...|.::|...|...:.
  Rat   213 GSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPLAEKIAVVSGCKSTT 277

  Fly   275 NEKEVFRYLQKAPASEMAAQGITL------VSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREM 333
            :...|....||. ..|:....:.|      :..:.|:.|   ||.|.|...:    |||:...|:
  Rat   278 SAAMVHCLRQKT-EEELLETTLKLNLFSLDLHGDSRQSY---PFVPTVLDGV----VLPKMPEEI 334

  Fly   334 LPEAWGNDLPLILGGNSFE------GLFSYQSTLHDEEHML-------SAFEVLIPREIREKSTQ 385
            |.|...|.:|.|:|.|..|      .:.:|..:....:.|.       |:|.:.:|.|....:.:
  Rat   335 LAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLPEEAIPVAVE 399

  Fly   386 SHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVD 450
            .:|:         :.||..|.:   ::.|.::....|  |:...:::|........||:|.|..
  Rat   400 KYLR---------HTDDPDRNK---DQLLELIGDVIF--GVPSVIVSRGHRDAGARTYMYEFQY- 449

  Fly   451 SPHFNHFRQVMCGKHVRGVSHADDLSYLF-YHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPN 514
            .|.|:   ..|....|.| .|.|::..:| ..||.....|.  |....:.::..|..||||.|||
  Rat   450 RPSFS---SKMKPSTVVG-DHGDEIYSVFGAPILRGGTSKE--EINLSKMMMKFWANFARNGNPN 508

  Fly   515 CPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRL 558
            ..  |...|...|:|  :..|.||...:.....:.|:...|..|
  Rat   509 GQ--GLPHWPEYDQK--EGYLQIGATTQQAQKLKEKEVAFWSEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	165/545 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	50/120 (42%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	166/559 (30%)
		Aes	43..>239	CDD:223730	80/202 (40%)
		Prevents secretion from ER (Potential)	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810