DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	560	Identity:	127/560 - (22%)
Similarity:	214/560 - (38%)	Gaps:	146/560 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LGTKQTKVVCTRD----GQVRGHRRRTLYDE---EMYFAFEGIPFAQPPVGELRFRAPQP----- 79
            ||:|.    ||.:    |.:.|   .|:.||   |....|.||.:|:||||:||:|.|..
pombe     8 LGSKP----CTLNIPGMGVLHG---LTVLDENGKEKCHRFTGIRYAKPPVGKLRWRRPVTLEDGY 65

  Fly    80 -------------PHPWLGVR-------DCTYPRAKPMQKHFVLSIVEGSEDCLYLNVYSKRLRS 124
                         |.|:...|       |..|                 .||||:||::..  ..
pombe    66 DYSGDYNQFKTICPQPFYNNRKNQVRNPDFKY-----------------DEDCLFLNIWVP--AG 111

  Fly   125 DKPL---PVIVWIYGGGFQFGEAGRDFYSPDYFMQ---QDV---------VVVTFNYRVGALGFL 174
            :||.   ||:.:|:||..|.|       :|.::.|   ||:         ::|:..:|:...|||
pombe   112 EKPAEGWPVLYFIHGGWLQVG-------NPLHYRQCDPQDLQADGSPAKFILVSPGHRLNLFGFL 169

  Fly   175 S---LADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTE---- 232
            :   |.:.| ....|.|..||.:.|.|..::|..|.|:.:||.|.|.|||:.|....:..|
pombe   170 AGKELLEED-PKSSNFGFWDQRLGLEWTYKHIESFGGNKENIAVGGISAGSYSALFQLIYETYHP 233

  Fly   233 QTRGLFHKAIMQSGSMFCEWAN-EPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGI 296
            :...:..:|::.|..:..:..: |.|......||.:.|.....:..|....|:..|..::|...:
pombe   234 EANQIIKRALLLSNGLSVQPKSVEESQIQFNELAQKFGIPLELSSAEKLEKLRAIPFQDLADNIL 298

  Fly   297 TLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDL-----PLILGG-NSFEGLF 355
            .|         .|..|..|.:    .|.|.|...:::....:|..:     .||:|. |:...::
pombe   299 NL---------RLHTFRAVTD----GDFVNPNTFKDIYDGTFGKRIRDSGRELIIGEVNNEHSIY 350

  Fly   356 SYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQF-KVDNFDDATRGRMEFNECLHILSV 419
            :..:....:|.:.:......|    ||.|    |.||..: ||.:.:|         |..::.::
pombe   351 ANTNPPKSKEDLFNQVNNYYP----EKVT----KALLELYPKVPDMED---------EKEYLAAI 398

  Fly   420 KHFWHGI---------HRTVLARL--SHAPATPTYLYRFDVDSPHFNHFR--QVMCGKHVRGVSH 471
            |..:..|         .|.::..|  ...|....|.||.......|:.:.  :.:       |.|
pombe   399 KALFGSIVSDMQVYASTRVLINGLVKGGVPLEKIYRYRIAFRGKFFDKYEPPESL-------VPH 456

  Fly   472 ADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARND 511
            |.||...||:::...:.:....|:...:..|.|::..:.|
pombe   457 AGDLGLWFYNVVDGILPEEIPIYKAWLKSYGEWMSTGKTD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	126/559 (23%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	38/137 (28%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	122/544 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050