DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and Tg

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	134/518 - (25%)
Similarity:	208/518 - (40%)	Gaps:	130/518 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 FAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQKHFVLSIVEG---------SEDC 112
            :.|.|:|:|.||:.|.||:||:..: |.|..|.|..|:...|        .|         ||||
  Rat  2227 YQFLGVPYAAPPLAENRFQAPEVLN-WTGSWDATKLRSSCWQ--------PGTRTPTPPQISEDC 2282

  Fly   113 LYLNVY-SKRLRSDKPLPVI----VWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALG 172
            |||||: .:.|.|:..:.|.    |.:.|.|.|....|....:..     :::|||.|||:|..|
  Rat  2283 LYLNVFVPENLVSNASVLVFFHNTVEMEGSGGQLNIDGSILAAVG-----NLIVVTANYRLGVFG 2342

  Fly   173 FLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGA--ASVHALMTTEQTR 235
            |||....  :|.||.||.|||.||.|:..:|..|.||||.:|:..:..||  ||:|.|:|.....
  Rat  2343 FLSSGSD--EVAGNWGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVASIHLLITRPTRL 2405

  Fly   236 GLFHKAIMQSGSMFCEWA---NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGIT 297
            .||.||::..||.....|   .:.:.:.|..||.::|...|..::.|..:.|| ||:.:......
  Rat  2406 QLFRKALLMGGSALSPAAIISPDRAQQQAAALAKEVGCPNSSVQEVVSCFRQK-PANILNEAQTK 2469

  Fly   298 LVSQEERRQYVLFPF---TPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQS 359
            |::       |..||   .|||:....|:....|..|. ||.    .:.|::||:..:||.:...
  Rat  2470 LLA-------VSGPFHYWGPVVDGQYLRELPSRRLKRP-LPV----KVDLLIGGSQDDGLINRAK 2522

  Fly   360 TLHDEE------HMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLH--- 415
            .:...|      :..:||...:...:..:.:.:.:  |.......:.:.:|.....|:..|.
  Rat  2523 AVKQFEESQGRTNSKTAFYQALQNSLGGEDSDARI--LAAAIWYYSLEHSTDDYASFSRALENAT 2585

  Fly   416 --------ILSVKHFW------------------HGIHRTVLARLSHAPATPTYLYRFDVDSPHF 454
                    |:::...|                  || ...:||.:.:|...|.|       |.:.
  Rat  2586 RDYFIICPIVNMASLWARRTRGNVFMYHVPESYGHG-SLELLADVQYAFGLPFY-------SAYQ 2642

  Fly   455 NHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVA-FARNDNPNCP 516
            .:|                                 |||.|::...|..:.: |.|:.|||.|
  Rat  2643 GYF---------------------------------SMEEQSLSLKVMQYFSNFIRSGNPNYP 2672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	134/518 (26%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	45/122 (37%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		134/518 (26%)
		COesterase	2198..2719	CDD:278561	134/518 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930