DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Cel

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	169/568 - (29%)
Similarity:	248/568 - (43%)	Gaps:	98/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VCTRDGQVRG-HRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHP-WLGVRDCTYPRAKPM 97
            |.|..|.|.| :::.:|...:....|:|||||.....|    .|| .|| |.|....|..:.:.:
  Rat    26 VYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLE----NPQ-RHPGWQGTLKATDFKKRCL 85

  Fly    98 QKHFVLSIVEGSEDCLYLNVY----SKRLRSDKPLPVIVWIYGGGFQFGEA-GRDFY------SP 151
            |.........|.|||||||::    .|::..|  |||:||||||.|..|.. |.:|.      ..
  Rat    86 QATITQDDTYGQEDCLYLNIWVPQGRKQVSHD--LPVMVWIYGGAFLMGSGQGANFLKNYLYDGE 148

  Fly   152 DYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVM 216
            :...:.:|:|||||||||.|||||..|.:|  |||.||:||.||:.|:.:|||.|.|||.|||:.
  Rat   149 EIATRGNVIVVTFNYRVGPLGFLSTGDANL--PGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIF 211

  Fly   217 GESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA-NEPSGRWAYRLACQLGYSGSENEKEVF 280
            |||||||||.....:...:||..:||.|||.....|| .|....||..:|.::|....:..|...
  Rat   212 GESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTAKMAG 276

  Fly   281 RYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLI 345
            ......|.:...|..:.|.|||....:.| .|.|||:             .:.:|     |.|:.
  Rat   277 CLKITDPRALTLAYRLPLKSQEYPIVHYL-AFIPVVD-------------GDFIP-----DDPIN 322

  Fly   346 LGGNSFEGLFSYQSTLHD-EEHMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRME 409
            |..|:.:  ..|.:.::| :.|:.:..:|....:.::..|:.....|:....|......|:...:
  Rat   323 LYDNAAD--IDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFD 385

  Fly   410 -FNECLHILSVKHFW------HGIHRTVLA-----------------RLSHAPATPTYLYRFDVD 450
             :.|.         |      ..:.:||:|                 ..:||.:..||.|.|...
  Rat   386 IYTES---------WAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHP 441

  Fly   451 SPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNC 515
            |      |..:..|.: |..|||||.|:|....|..:...:.:....:.::..|..||::.:||
  Rat   442 S------RMPIYPKWM-GADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPN- 498

  Fly   516 PQIG----PTTW-EALDEKGPQMCLNIGKQLEFIVLPE---SKQNRIW 555
              :|    ||.| ....|.|..  |:|.|::....:.|   .|..:.|
  Rat   499 --MGNSPVPTHWYPYTTENGNY--LDINKKITSTSMKEHLREKFLKFW 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	166/549 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	61/126 (48%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	168/566 (30%)
		Aes	<118..>247	CDD:223730	66/130 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640