DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and Ces2c

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	550	Identity:	167/550 - (30%)
Similarity:	244/550 - (44%)	Gaps:	98/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQK-- 99
            |..||::|........:.....|.|||||:||||.|||..|:.|.||.||||.|...|..:|.
Mouse    38 THTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLD 102

  Fly   100 ----------HFVLSIVEGSEDCLYLNVYS-KRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDY 153
                      ..:||....||||||||:|: ........|||:|||:||....|.|.. |.....
Mouse   103 MLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASM-FDGSLL 166

  Fly   154 FMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGE 218
            .:.:|:||||..||:|.|||.|..|:  ...||.|..||..||||:.||||.|.|:|..:|:.||
Mouse   167 TVNEDLVVVTIQYRLGVLGFFSTGDQ--HARGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGE 229

  Fly   219 SAGAASVHALMTTEQTRGLFHKAIMQSG-SMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRY 282
            |||..||.:.:.:..::||||.|||:|| ::..:..:|.|...:..:|...|....:::..|...
Mouse   230 SAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDSQALVRCL 294

  Fly   283 LQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILG 347
            ..|:.|..:|...:             |...|.|    ......||..:|:|.....:.:|.|:|
Mouse   295 RGKSEAEILAINKV-------------FKMIPAV----VDGEFFPRHPKELLASEDFHPVPSIIG 342

  Fly   348 GNSFEGLFS------------------YQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQ 394
            .|:.|..:|                  .|:.|.|     :|.::::|.|         ..|||.:
Mouse   343 VNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKD-----TAVQMMLPPE---------CSDLLME 393

  Fly   395 FKVDNFDDATRGRMEFNE-------CLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSP 452
            ..:.:.:||...:::|.|       .:..|.|.||          :.|||   |.|.|.|.....
Mouse   394 EYMGDTEDAQTLQIQFTEMMGDFMFVIPALQVAHF----------QRSHA---PVYFYEFQHPPS 445

  Fly   453 HFNHFRQVMCGKHVRGVSHADDLSYLFYHIL-ANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCP 516
            :|...|.    .||: ..|||::.::|.... ..|:|.:..|....:|::..|..|||:.|||..
Mouse   446 YFKDVRP----PHVK-ADHADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSE 505

  Fly   517 QIGPTTWEALDEKGPQMCLNI----GKQLE 542
              |...|..:|.....:.|:|    |:.|:
Mouse   506 --GLPYWPVMDHDEQYLQLDIQPAVGRALK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	166/547 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	49/116 (42%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	167/549 (30%)
		Aes	<130..>233	CDD:223730	46/105 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640