DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ces2b

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	597	Identity:	179/597 - (29%)
Similarity:	260/597 - (43%)	Gaps:	118/597 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLLKMG-TKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGEL 72
            |:|..| ..|:||  ||.:...:.:.:..|..|||||........:.....|.|||||:||||.|
Mouse    11 DVLLFGLLLLLGH--VQGQDSPEASPIRNTHTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPL 73

  Fly    73 RFRAPQPPHPWLGVRDCTYPRAKPMQ-----KHFVLSI--VEGSEDCLYLNVYS-KRLRSDKPLP 129
            ||..|:.|.||.||||.|...|..:|     |...|.:  |..||||||||:|: ........||
Mouse    74 RFAPPEAPEPWSGVRDGTAHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSNLP 138

  Fly   130 VIVWIYGGGFQFGEAGRDFYSPDYFMQ-QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQV 193
            |:|||:|||...|.|  ..|....... :|:||||..||:|.|||.|..|:  ...||.|..|||
Mouse   139 VMVWIHGGGLVAGMA--SMYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQ--HARGNWGFLDQV 199

  Fly   194 MALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSG 258
            .|||||.||||.|.|.|..:|:.|||||..||.:.:.:..::||||.|||:||.....:....:.
Mouse   200 AALRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLITDTS 264

  Fly   259 RWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRD 323
            ........:|....:.:.:.:.|.|:....:|:.|  |..:.|              :.|.:...
Mouse   265 EMVSTTVAKLSGCEAMDSEALVRCLRGKSEAEILA--INKLVQ--------------MIPAVVDG 313

  Fly   324 CVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIP---------REI 379
            ...||..:|:|.....:.:|.|:|.|:.|                  |...||         :||
Mouse   314 EFFPRHPKELLASEDFHPVPSIIGVNNDE------------------FGWTIPVVMGSAQTIKEI 360

  Fly   380 REKSTQSHLK-------------DLLRQFKVDNFDDATRGRMEFNECLH-------ILSVKHFWH 424
            ..::.|:.||             |||.:..:.:.:||...:::|.|.:.       .|.|.:|
Mouse   361 TRENLQAVLKNTTAQLMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMEDFMFVIPALQVAYF-- 423

  Fly   425 GIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVR----GVSHADDLSYLF-YHILA 484
                    :.|||   ..|.|.|.         .|:...|.||    ...|||::.::| |....
Mouse   424 --------QRSHA---SVYFYEFQ---------HQIASLKDVRPTHVKADHADEIPFVFGYFFWD 468

  Fly   485 NKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLN----IGKQLEFIV 545
            .|:|.:..|....:|::..|..|||:.|||..  |...|..:|.....:.|:    :|:.|
Mouse   469 MKLDFTEGEKLLSRRMMKYWANFARHGNPNSE--GLPYWPVMDHDEQYLQLDTQPAVGRAL---- 527

  Fly   546 LPESKQNRIWDR 557
              :|::.:.|.:
Mouse   528 --KSRRLQFWTK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	168/559 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	52/117 (44%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	170/568 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640