DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ces1f

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	557	Identity:	169/557 - (30%)
Similarity:	243/557 - (43%)	Gaps:	105/557 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC-TYPRAKPM 97
            ||.|..|:|.|.........:....|.|||||:||:|.|||..|||..||..|::. |||   ||
Mouse    25 VVDTAHGKVLGKHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYP---PM 86

  Fly    98 ------QKHFVLSIV---------EGSEDCLYLNVY-----SKRLRSDKPLPVIVWIYGGGFQFG 142
                  :...|..::         |.||||||||:|     ||..|    |||:|||:|||.:.|
Mouse    87 CSQDAARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNSR----LPVMVWIHGGGLKLG 147

  Fly   143 EAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFN 207
            .|. .|........::||||...||:...||.|..|.  ...||.|..|||.||.|:..|||.|.
Mouse   148 GAS-SFDGRALSAYENVVVVAIQYRLSIWGFFSTGDE--HSRGNWGHLDQVAALHWVQDNIANFG 209

  Fly   208 GDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSG-----SMFCEWANEPSGRWAYRLACQ 267
            |||.::|:.|||||..||..|:.:..::.|||:||.:||     .||.:.....:.:.|....|:
Mouse   210 GDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGCK 274

  Fly   268 LGYSG-------SENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCV 325
            ...|.       .:.|:|:...:.|....:::.||.|..|.    |:|    |.|::     ..|
Mouse   275 TTTSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGDTKNSD----QFV----TSVLD-----GVV 326

  Fly   326 LPRCHREMLPEAWGNDLPLILGGNSFE---------GLFSYQSTLHDEEHMLSAFEVL-----IP 376
            ||:..:|:|.|...|.:|.|:|.|..|         |.......| |::..::..|..     ||
Mouse   327 LPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKL-DKKKAIALLEQFASMTGIP 390

  Fly   377 REIREKSTQSHLK-----DLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSH 436
            .:|...:.:.:.|     |.:|:..:|...|..                   .|:...:::|...
Mouse   391 EDIIPVAVEKYTKGSDDPDQIREGVLDAMGDVA-------------------FGVPSVIVSRGHR 436

  Fly   437 APATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLV 501
            ....|||:|.:.    ::..|......|:|.| .||||: |..:.....:...|..|....:.::
Mouse   437 DTGAPTYMYEYQ----YYPSFSSPQRPKNVVG-DHADDV-YSVFGAPILREGASEEEINLSKMVM 495

  Fly   502 GMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIG 538
            ..|..||||.|||..  |...|...|:|  :..|:||
Mouse   496 KFWANFARNGNPNGK--GLPHWPKYDQK--EGYLHIG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	169/557 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	51/120 (43%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	169/557 (30%)
		Aes	<121..>225	CDD:223730	48/110 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650