Protein Alignment alpha-Est1 and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 157/608 - (25%)
• Similarity: 254/608 - (41%)
• Gaps: 135/608 - (22%)

  Fly    31 QTKVVCTRDGQVRGHR----RRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTY 91
            |..||.|..|:::|.|    ...|...|.|.   |:|:|.||.||.||:.|:.|..|.|:|:.|.
Human    44 QYPVVNTNYGKIQGLRTPLPSEILGPVEQYL---GVPYASPPTGERRFQPPESPSSWTGIRNATQ 105

  Fly    92 PRA---KPMQKHFVLS-----------------IVEGSEDCLYLNVY-----------------S 119
            ..|   :.:.:.|:|.                 :.:.:|||||||:|                 |
Human   106 FSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITS 170

  Fly   120 KRLRSDKPL-------PVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLA 177
            .....||.:       ||:|:|:||.:..| .|............:|:|:|.|||:|.|||||..
Human   171 NDHGEDKDIHEQNSKKPVMVYIHGGSYMEG-TGNMIDGSILASYGNVIVITINYRLGILGFLSTG 234

  Fly   178 DRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAI 242
            |:  ...||.||.||:.|||||.:|:..|.|||:.:|:.|..|||:.|..|..:..:.|||.|||
Human   235 DQ--AAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAI 297

  Fly   243 MQSGSMFCEWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQ 306
            :|||:....|| |....::...||.::|.:..:. .::...|:.....|:..|.||..:..
Human   298 IQSGTALSSWAVNYQPAKYTRILADKVGCNMLDT-TDMVECLKNKNYKELIQQTITPATYH---- 357

  Fly   307 YVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHML-SA 370
               ..|.||::     ..|:|...:.::.:....:..::||.|..|||......:.:|:.:. :.
Human   358 ---IAFGPVID-----GDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPND 414

  Fly   371 FEVLIPREIREKSTQSHLKDLLRQ---FKVDNFDD----ATRGRMEFNECLHILSVKHFWHGIHR 428
            |:..:...:.........||.||:   |...::.|    .||     .:.|..|...|.|  :..
Human   415 FDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETR-----RKTLVALFTDHQW--VAP 472

  Fly   429 TVLARLSHAP-ATPTYLYRFDVDSPHFNHFRQVMCGKHVR----GVSHADDLSYLF-------YH 481
            .|.....||. .:|||.|.|      ::|     |...::    ..:|.|::.|:|       ..
Human   473 AVATADLHAQYGSPTYFYAF------YHH-----CQSEMKPSWADSAHGDEVPYVFGIPMIGPTE 526

  Fly   482 ILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVL 546
            :.:....|:.:....:  ::..|..||:..:||.|                    :.:..:||
Human   527 LFSCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQP--------------------VPQDTKFI-- 567

  Fly   547 PESKQNRI----WDRLYDKNDLF 565
             .:|.||.    |.:...|:.|:
Human   568 -HTKPNRFEEVAWSKYNPKDQLY 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	149/578 (26%)
		Aes	<117..>233	CDD:223730	48/139 (35%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	156/606 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840