Protein Alignment alpha-Est1 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 597
• Identity: 170/597 - (28%)
• Similarity: 261/597 - (43%)
• Gaps: 118/597 - (19%)

  Fly    27 LGTKQTKVVCTRDGQVRGHRRRTLYDEEM--YFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC 89
            ||.::..||.|..|:|||.||. |.:|.:  ...|.|:|:|.||:|..||:.|:.|..|.|||:.
Mouse    36 LGEERFPVVNTAYGRVRGVRRE-LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNA 99

  Fly    90 -TYPRAKPMQKHFVLSIV------------------EGSEDCLYLNVY---------SKR----- 121
             |.|.|.|...|..|..:                  ..||||||||:|         .||
Mouse   100 TTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATL 164

  Fly   122 ------LRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRD 180
                  :|.....||:::::||.:..| .|..|.........:|:|||.|||:|.|||||..|:
Mouse   165 NPPDTDIRDSGKKPVMLFLHGGSYMEG-TGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQ- 227

  Fly   181 LDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQS 245
             ...||.||.||:.||||:|:|||.|.|||:.||:.|..|||:.|:.|:.:..:.|||.|||.||
Mouse   228 -AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQS 291

  Fly   246 GSMFCEWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVL 309
            |:....|: |....::...||.::| ...|:..|....|::..:.|:..|.:     :..|.::
Mouse   292 GTAISSWSVNYQPLKYTRLLAAKVG-CDREDSTEAVECLRRKSSRELVDQDV-----QPARYHI- 349

  Fly   310 FPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHM-LSAFEV 373
             .|.|||:     ..|:|.....::.:....:..:::|.|..|||...:.:...|:.: .|||:.
Mouse   350 -AFGPVVD-----GDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDF 408

  Fly   374 LIPREIREKSTQSHLKDLLRQ---FKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLS 435
            .:...:.........||:||:   |...::.|...|.|. .:.|..|...|.|  :...|.....
Mouse   409 TVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMR-RKTLLALFTDHQW--VAPAVATAKL 470

  Fly   436 HAP-ATPTYLYRFDVDSPHFNHFRQVMCGKHVR----GVSHADDLSYLFYHILANKVD------- 488
            ||. .:|.|.|.|      ::|     |....|    ..:|.|:|.|:|...:....|
Mouse   471 HADYQSPVYFYTF------YHH-----CQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFS 524

  Fly   489 KSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNR 553
            |:.:....:  ::..|..||:..:||.|                    :.:..:||   .:|.||
Mouse   525 KNDVMLSAV--VMTYWTNFAKTGDPNQP--------------------VPQDTKFI---HTKPNR 564

  Fly   554 ----IWDRLYDK 561
                :|.:...|
Mouse   565 FEEVVWSKFNSK 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	166/585 (28%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	168/591 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836