DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and Ces2e

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	177/567 - (31%)
Similarity:	259/567 - (45%)	Gaps:	110/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TRDGQVRG---HRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQ 98
            |..|||||   |.:.|   :.....|.|||||:||:|.|||..|:||.||.||||.|...|..:|
  Rat    36 THTGQVRGSFVHVKDT---KSGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQ 97

  Fly    99 KHFVLSI-----------VEGSEDCLYLNVYS-KRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSP 151
            ....|::           |..|||||||::|: .....|..|||:|||:|||..:|.|..  |..
  Rat    98 NIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMAST--YDG 160

  Fly   152 DYFMQ-QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITV 215
            ..... :||||||..||:|.|||.|..|.  ...||.|..|||.||||:.|||..|.|:|..:|:
  Rat   161 SMLAAIEDVVVVTIQYRLGILGFFSTGDE--HARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTI 223

  Fly   216 MGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAYRLACQLGYSGSE--NEKE 278
            .|||||..||.:.:.:..::||||.|||:||..........:....|.:...|  ||.|  :.:.
  Rat   224 FGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEVIYTMVANL--SGCEPVDSEA 286

  Fly   279 VFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLP 343
            :...|::....||.|           ...::...:.||:...     |||...|:|.....:.:|
  Rat   287 LMSCLREKSEEEMLA-----------INNIVRTISGVVDGKF-----LPRHPLELLASVDFHPVP 335

  Fly   344 LILGGNSFEGLFSYQ---STLHDEEHMLSAFEVLIPREIREKSTQSHLK-------------DLL 392
            .|:|.||.|    |.   ..||.:..|         :||..::.::.||             |||
  Rat   336 SIIGINSDE----YGWIIPMLHPDSTM---------KEINRETMRAVLKNTAVQMMLPPECSDLL 387

  Fly   393 RQFKVDNFDDATRGRMEFNE-------CLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVD 450
            .:..:.:.:|:...:::|||       .:..|.|.||          :.|||   |.|.|.|.
  Rat   388 MEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQVAHF----------QRSHA---PVYFYEFQ-- 437

  Fly   451 SPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQR-LVGMWVAFARNDNPN 514
              |.::|.:.:...||: ..|.|:|.|:..::..:.....:.|.:.:.| ::..|..|||:.|||
  Rat   438 --HQSNFLKDIRPPHVK-ADHGDELPYVIGYLFWDMKFVFTEEEKLLSRKMIKYWANFARHGNPN 499

  Fly   515 CPQIGPTTWEALDEKGPQMCLNI----GKQLEFIVLPESKQNRIWDR 557
            ..  |...|.|||.....:.|:|    |:.|      ::::.:.|.:
  Rat   500 SE--GLPYWPALDHDEQYLQLDIQPVVGRAL------KARRLKFWTK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	175/549 (32%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	52/117 (44%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	176/563 (31%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	49/106 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640