Protein Alignment alpha-Est1 and Nlgn1

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 671
• Identity: 172/671 - (25%)
• Similarity: 269/671 - (40%)
• Gaps: 205/671 - (30%)

  Fly    34 VVCTRDGQVRGHRRRTLYDEEM--YFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAK 95
            :|.|..|::||.::. |.:|.:  ...|.|:|:|.||.||.||:.|:||.||..:|:.| :....
Mouse    54 LVTTNFGKIRGIKKE-LNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVC 117

  Fly    96 PMQKHFVLSIVEG-------------------------SEDCLYLNVY-----SKRLR------- 123
            |.      :|::|                         ||||||||:|     .||:.
Mouse   118 PQ------NIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKP 176

  Fly   124 --------------------------------SDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQ 156
                                            |..|.||:|:|:||.:..|..  :.|.......
Mouse   177 GKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTG--NLYDGSVLAS 239

  Fly   157 Q-DVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESA 220
            . :|:|:|.|||:|.|||||..|:  ...||.||.|.:.||||.|:||..|.|||..|||.|..|
Mouse   240 YGNVIVITVNYRLGVLGFLSTGDQ--AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGA 302

  Fly   221 GAASVHALMT---------TEQTRGLFHKAIMQSGSMFCEWA--NEPSGRWAYRLACQLGYSGSE 274
            |.:.|:.|..         :..|:|||.:||.|||:....||  .:|: ::|..||.::|.:.|:
Mouse   303 GGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPA-KYARILATKVGCNVSD 366

  Fly   275 NEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWG 339
            . .|:...|||.|..|:..|.:     :..|.::.|      .|.|..| |:|...:.::.:...
Mouse   367 T-VELVECLQKKPYKELVDQDV-----QPARYHIAF------GPVIDGD-VIPDDPQILMEQGEF 418

  Fly   340 NDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQFKVDNFDDAT 404
            .:..::||.|..||| .:...:.|.:..:||.:.                    .|.|.||.|..
Mouse   419 LNYDIMLGVNQGEGL-KFVENIVDSDDGVSASDF--------------------DFAVSNFVDNL 462

  Fly   405 RGRMEFNECLHILSVKHF---WHGIH------RTVLARLSH----APA-----------TPTYLY 445
            .|..|..:.|. .::|..   |...|      :|:||..:.    |||           :|||.|
Mouse   463 YGYPEGKDVLR-ETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFY 526

  Fly   446 RFDVDSPHFNHFR--QVMCGKHVRGVSHADDLSYLF-------YHILANKVDKSSMEYQTIQRLV 501
            .|      ::|.:  ||...   ...:|.|::.|:.       ..:......|:.:....:  ::
Mouse   527 AF------YHHCQTDQVPAW---ADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAV--VM 580

  Fly   502 GMWVAFARNDNPNCP-------------QIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQN- 552
            ..|..||:..:||.|             :.....|....:| .|:.|:||      :.|..|::
Mouse   581 TYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQK-DQLYLHIG------LKPRVKEHY 638

  Fly   553 -----RIW----DRLYDKNDL 564
                 .:|    ..|::.||:
Mouse   639 RANKVNLWLELVPHLHNLNDI 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	166/636 (26%)
		Aes	<117..>233	CDD:223730	50/169 (30%)
Nlgn1	XP_006535478.1	COesterase	53..646	CDD:365897	168/656 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740