Protein Alignment alpha-Est1 and cest-28

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_504691.2
• Gene: cest-28 / 187305
• WormBaseID: WBGene00019654
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 168/583 - (28%)
• Similarity: 263/583 - (45%)
• Gaps: 113/583 - (19%)

  Fly    25 YRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC 89
            ||:|.|      |.||                  :.|||||:|.|   ||:.|:|...|..||||
 Worm    29 YRIGDK------TVDG------------------YLGIPFAKPLV---RFKKPEPAGTWEEVRDC 66

  Fly    90 T-----YPRAKPMQK--HFVLSIVEGSEDCLYLNVYSKRLRS---DKPLPVIVWIYGGGFQFGEA 144
            |     .|::.|..:  :|....:....:||.|||:||...|   :|..||:|:|:|||::. .|
 Worm    67 TKYGPRCPQSGPFAEAINFQKDDIPDEANCLTLNVFSKISDSKNFNKTRPVMVYIHGGGYEC-SA 130

  Fly   145 GRDFYSPDYFMQ-----QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIA 204
            .||:.  ||.:.     :||||||.|||||.|||.:..  |...|||..|.|..:.|.||.::|.
 Worm   131 SRDYC--DYSVAGTLPLKDVVVVTLNYRVGILGFFTTG--DTVCPGNFALWDLTLGLNWIQKHIE 191

  Fly   205 QFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWA---YRLAC 266
            .|.|||.|||:.|:|||||.|..|..:..:|.||::.|:.||...||:|...:...|   |..|.
 Worm   192 SFGGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEFAR 256

  Fly   267 QLGYSGSENEKEVFRYLQKAPASE--------MAAQGITLVSQEERRQYVLFPFTPVVEPYITRD 323
            .|||.|: |.:.:|.:::..|..|        :.|.||             ..:||.::     |
 Worm   257 HLGYDGT-NSQTLFNWMKSKPLEEIEKMNGFQVPASGI-------------LAWTPNLD-----D 302

  Fly   324 CVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHL 388
            ...|:...|:...|...|  :::|....|||| ::..:.|....|.|.::.: .|..:|.|..|.
 Worm   303 DFFPKSLDELRIGAPKKD--IMMGFAEHEGLF-FEFLIKDPTPPLEALKLYV-NEYYKKDTGDHF 363

  Fly   389 ---KDLLRQFKVDNFDD----ATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYR 446
               ::.:.:|...|.:|    :|:.|:     :..:....|..|:.......|.|  ....:||.
 Worm   364 EATRNKIIEFYSRNVEDTDEKSTKERL-----IDFVGDALFTAGVFDNAKNCLKH--GNNVWLYI 421

  Fly   447 FDVDSPH-FNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARN 510
            ||..:|. |.:..:.|.   ....:|..||.|:....|.:....:..|::.|:::..::..||:.
 Worm   422 FDYCNPSGFGNQEEFMT---FVAPTHCTDLRYVLGEGLYSDFQPTEEEHKMIEKMTTIYSNFAKY 483

  Fly   511 DNPNCPQIGPTTWEALDEKGPQMCLNI----GK--------QLEFIVLPESKQNRIWDRLYDK 561
            .|||  :.|.:.||......|:....|    ||        :::|:.|..:|...:.:.:|.:
 Worm   484 GNPN--EHGSSEWEKFTLDNPRRHFQISYPRGKMRNDYHPDRMKFLELIRAKNQNLENVVYGR 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	162/558 (29%)
		Aes	<117..>233	CDD:223730	56/123 (46%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	164/553 (30%)
		Aes	<112..>222	CDD:223730	52/114 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720