DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cest-30

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	585	Identity:	157/585 - (26%)
Similarity:	255/585 - (43%)	Gaps:	110/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC-TYPR 93
            |.::::....|.:||:..:.....::...:.|||||:.|||.|:|:.|.....|...||| .|..
Worm    29 KNSQILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVGALKFKKPVAAEKWTEPRDCYEYGP 93

  Fly    94 AKPMQKHFVLSIVEGS-----EDCLYLNVYSKRLR---SDKPLPVIVWIYGGGFQFGEAGRDFYS 150
            ..|....|.....:.:     |:||.|||::.|.:   ..|.|||:|:|||||::.|...   |.
Worm    94 GCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPKGLPVLVYIYGGGYEIGFTS---YM 155

  Fly   151 PDYFMQ-----QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDP 210
            .||.:.     :||:|||.|||:|.||||::||...:  ||.||.||.:||:|:..|||.|.|:|
Worm   156 DDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIAN--GNYGLWDQTLALQWVQDNIASFGGNP 218

  Fly   211 QNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPS----GRWAYRLACQ---- 267
            :::|:.|.||||.|...|..:..:..||.::|..||:.||.:|..|.    |      .|:
Worm   219 ESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFAIRPKDVEVG------VCKEFAQ 277

  Fly   268 -LGYSGSENE--------KEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRD 323
             .||:|::::        :.|.::.:.|.....||..:..:...: ..:...||..:......:|
Worm   278 FQGYTGTDSQSLFDWYMAQNVSKFKEVAGFQSTAAGAVPFIPNFD-GDFFPKPFDILRREAPKKD 341

  Fly   324 CVLPRCHREMLPEAWGNDLPLILGG-NSFEGLF--SYQSTLHDEEHMLSAFEVLIPREIREKSTQ 385
            .::.....|.:.....|  ||.... |:|||..  :|...:.|           ...::::|.|.
Worm   342 ALITVVTMESVGMIIFN--PLFANAYNNFEGFINETYGPDVTD-----------YYADVKKKLTG 393

  Fly   386 SHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHA-------PATPTY 443
            .:|||      |:..|.||                     ::|.|:..:|.:       .|..:|
Worm   394 FYLKD------VNASDKAT---------------------VNRRVVDYVSDSVFNSGTLDAVKSY 431

  Fly   444 L-YRFDVDSPHFNHFR-----QVMCGKHVRGVSHADDLSYLF-YHILANKVDKSSMEYQTIQRLV 501
            : |...|....||:|.     .|...:..:..||:.|..|.| ..::||.....  |...:..:.
Worm   432 VKYGNKVYLGSFNYFNDATKDMVELMQPFKEASHSSDFKYYFGSGVMANFTPTD--EEMEVMDMS 494

  Fly   502 GMWVA-FARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQN---RIWDRLYDKN 562
            |..:| |.:..:|| .:.|...|:......|.|...|  ......:.::.||   ||:|.: :||
Worm   495 GTLMANFVKYGDPN-GKSGTKPWKPYTILKPNMYYKI--DYPTCEMSDNFQNGRLRIYDDI-NKN 555

Fly 563 562
Worm 556 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	150/559 (27%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	54/123 (44%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	149/564 (26%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	50/112 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650