Protein Alignment alpha-Est1 and cest-3

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 584
• Identity: 129/584 - (22%)
• Similarity: 222/584 - (38%)
• Gaps: 163/584 - (27%)

  Fly    25 YRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC 89
            :.|.....:::.|..|::.|  :....|:.|   |:.:|||:||:|:|||..|:..:||..:|:.
 Worm    14 FTLNGSGQRIISTTYGKLEG--KTVNVDQHM---FKNVPFAKPPLGKLRFSLPEWTNPWKNIRNA 73

  Fly    90 T------YPRAK--------PMQKHFVLSIVEGSEDCLYLNVYSKR--LRSDKPLPVIVWIYGGG 138
            |      :..:.        ||           |||||||||::..  |:| |....:|:.:|||
 Worm    74 TEYSPSCFSNSSMRTDSNFFPM-----------SEDCLYLNVFTNEYCLKS-KNCSTVVYYHGGG 126

  Fly   139 FQFGEAGR--DFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQ 201
            .....|.:  |.:..:.:::::||.:...||:|..|.|.....:| ||.|..:.|..:|||:|.|
 Worm   127 INMDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNL-VPQNLAIHDCELALRFIHQ 190

  Fly   202 NIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGL--FHKAI--------MQSGSMFCEWANEP 256
            .|:.|.|...:|.:||.||||   |..:....:|.:  .||.|        :.|..| .|...:.
 Worm   191 EISNFGGHKDDINLMGHSAGA---HISLIFGFSRHIDPDHKLINRIIVLSPVPSYDM-PELLIKN 251

  Fly   257 SGRWAYRLACQLGY--SGSENEKEVFRYLQKAPA-SEMAAQGITLVSQEERRQYVLFPFTPVVEP 318
            ...:|.|:.|   |  :.:..:.|:.:.|:|..| ..|:.|.:    .|..|.|.
 Worm   252 CYDFAERVGC---YKRNVTARDTEIVKCLRKKDARGLMSMQRL----MENDRLYF---------- 299

  Fly   319 YITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKS 383
                               |.     .|.|..|         ::.:|.:....|..:.|::...:
 Worm   300 -------------------WN-----FLAGEPF---------MYRDESIADFKEYAVKRDMLIGN 331

  Fly   384 TQSHLKDLLRQFKVDNFDDATRGR-MEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRF 447
            |...:|  .::.|.:|  .|..|. |::.....:....:|:|          ..||...||
 Worm   332 TVDEVK--WKRLKKEN--PAIAGSFMDWENPYEVAHKFNFYH----------DSAPVNSTY---- 378

  Fly   448 DVDSPHFNHFRQ---VMCGKHVRGVSHADDLSYLF--------------YHILANKVDKSSMEYQ 495
                   ..|.|   |....:....::|....|||              |.:..::.|..:.:..
 Worm   379 -------ESFTQGIFVSTATYAEAQANAGGTVYLFQSNQQPSSHVSDMQYFVGTHREDYHTSDMD 436

  Fly   496 TIQRLVG-MWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRL 558
            .:..... |.|.|.:..:|:      ..||.|          :..::.:..|..:.:..||.|:
 Worm   437 IMDTFYSKMIVNFTKFGSPS------PVWEPL----------VPSRMNYYALEVNTEKGIWPRM 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	124/562 (22%)
		Aes	<117..>233	CDD:223730	38/119 (32%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	128/575 (22%)
		Aes	<118..>254	CDD:223730	41/140 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740