Protein Alignment alpha-Est1 and cest-3

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 584
• Identity: 129/584 - (22%)
• Similarity: 222/584 - (38%)
• Gaps: 163/584 - (27%)

  Fly    25 YRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC 89
            :.|.....:::.|..|::.|  :....|:.|   |:.:|||:||:|:|||..|:..:||..:|:.
 Worm    14 FTLNGSGQRIISTTYGKLEG--KTVNVDQHM---FKNVPFAKPPLGKLRFSLPEWTNPWKNIRNA 73

  Fly    90 T------YPRAK--------PMQKHFVLSIVEGSEDCLYLNVYSKR--LRSDKPLPVIVWIYGGG 138
            |      :..:.        ||           |||||||||::..  |:| |....:|:.:|||
 Worm    74 TEYSPSCFSNSSMRTDSNFFPM-----------SEDCLYLNVFTNEYCLKS-KNCSTVVYYHGGG 126

  Fly   139 FQFGEAGR--DFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQ 201
            .....|.:  |.:..:.:::::||.:...||:|..|.|.....:| ||.|..:.|..:|||:|.|
 Worm   127 INMDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNL-VPQNLAIHDCELALRFIHQ 190

  Fly   202 NIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGL--FHKAI--------MQSGSMFCEWANEP 256
            .|:.|.|...:|.:||.||||   |..:....:|.:  .||.|        :.|..| .|...:.
 Worm   191 EISNFGGHKDDINLMGHSAGA---HISLIFGFSRHIDPDHKLINRIIVLSPVPSYDM-PELLIKN 251

  Fly   257 SGRWAYRLACQLGY--SGSENEKEVFRYLQKAPA-SEMAAQGITLVSQEERRQYVLFPFTPVVEP 318
            ...:|.|:.|   |  :.:..:.|:.:.|:|..| ..|:.|.:    .|..|.|.
 Worm   252 CYDFAERVGC---YKRNVTARDTEIVKCLRKKDARGLMSMQRL----MENDRLYF---------- 299

  Fly   319 YITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKS 383
                               |.     .|.|..|         ::.:|.:....|..:.|::...:
 Worm   300 -------------------WN-----FLAGEPF---------MYRDESIADFKEYAVKRDMLIGN 331

  Fly   384 TQSHLKDLLRQFKVDNFDDATRGR-MEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRF 447
            |...:|  .::.|.:|  .|..|. |::.....:....:|:|          ..||...||
 Worm   332 TVDEVK--WKRLKKEN--PAIAGSFMDWENPYEVAHKFNFYH----------DSAPVNSTY---- 378

  Fly   448 DVDSPHFNHFRQ---VMCGKHVRGVSHADDLSYLF--------------YHILANKVDKSSMEYQ 495
                   ..|.|   |....:....::|....|||              |.:..::.|..:.:..
 Worm   379 -------ESFTQGIFVSTATYAEAQANAGGTVYLFQSNQQPSSHVSDMQYFVGTHREDYHTSDMD 436

  Fly   496 TIQRLVG-MWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRL 558
            .:..... |.|.|.:..:|:      ..||.|          :..::.:..|..:.:..||.|:
 Worm   437 IMDTFYSKMIVNFTKFGSPS------PVWEPL----------VPSRMNYYALEVNTEKGIWPRM 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	125/573 (22%)
cest-3	NP_510042.2	alpha/beta hydrolases	21..496	CDD:473884	128/577 (22%)