DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and cest-34

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001360105.1	Gene:	cest-34 / 179057	WormBaseID:	WBGene00019652	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	161/555 - (29%)
Similarity:	244/555 - (43%)	Gaps:	111/555 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LGTKQTKVVCTRDGQVRGHRRRTLY---DEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRD 88
            |||    |:.|..|.|.|:    ||   |:|:: .:.|:|:|:||.||:||..|.|...|...||
Worm    13 LGT----VLNTSCGPVLGN----LYRHGDKEVH-GYLGMPYAKPPTGEMRFAKPVPADDWTETRD 68

  Fly    89 CTY--PRAKP----MQKHFVLSIVEGSE-DCLYLNVYSKRLRSDK---PLPVIVWIYGGGFQFGE 143
            ||.  ||..|    ::|...::..|..| :.|.:||:.....|.:   ..||:|:::||||:. .
Worm    69 CTKYGPRCPPSGQGLEKGMFVNPDEPDEANGLSVNVFVPGWESSEYKNARPVMVYVHGGGFEI-S 132

  Fly   144 AGRDFYSPDYFM-----QQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNI 203
            :.|:|.  ||.:     .:||::||.|||:|.|||.:..|.  ..|||.||.||.:||:|:.::|
Worm   133 SSREFC--DYSISSTLPMKDVILVTMNYRLGILGFFTTGDE--VCPGNFGLWDQTLALQWVQKHI 193

  Fly   204 AQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAY---RLA 265
            |.|.|||.|:|:.|:|||.|.|..|..:..:|.||.|.:..|||..||:|...:...|:   .:.
Worm   194 ASFGGDPNNVTLFGQSAGGACVDLLTLSPHSRDLFQKVVPMSGSAMCEFAMRTAENEAHVFDDIL 258

  Fly   266 CQLGYSGSENEKEVFRYLQKAPASEMAAQ-GITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRC 329
            .:||::|| ..||...:::..|..::..: |.|         |....|..:...|  .....|:.
Worm   259 ARLGFTGS-GSKERLEFMRSLPCDKITGKTGYT---------YKQSGFMSLCPNY--DGDFFPKP 311

  Fly   330 HREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLR- 393
            ..|:..:|....|...:.||  |||             |.||:        ..:......||||
Worm   312 LDELRKDASKRILMTGIVGN--EGL-------------LFAFD--------RNTPYKDYTDLLRL 353

  Fly   394 ----QFKVDNFDDATRGRMEFNE-----------------CLHILSVKHFWHGIHRTVLARLSHA 437
                .:|.|..||....|.|..|                 ....:....|..|:..|......|
Worm   354 KIEEDYKEDVVDDVEGIRKEIFEYYTKNISEGDEEAIMRKAAEFVGDSIFHTGVRATAQNAAEH- 417

  Fly   438 PATPTYLYRFDVDSPHFNHFRQVMCGKHVRGV------SHADDLSYLFYHILANKVDKSSMEYQT 496
             ....:||.||..:|  :.|..      ::|.      :|..:|.|||...:.:|.:.:..|.:.
Worm   418 -GDEVWLYNFDYCNP--DGFAP------LKGYLPYIEPTHGMELRYLFGDGIISKFEPTEEELKM 473

  Fly   497 IQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGP 531
            :.:...|:..||:..|||  :.|.:.||..|...|
Worm   474 LDKFTTMFANFAKYGNPN--ETGSSAWEKFDPARP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	160/554 (29%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	50/123 (41%)
cest-34	NP_001360105.1	COesterase	15..530	CDD:365897	159/553 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14726
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.710