DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and cest-33

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_504621.1	Gene:	cest-33 / 179020	WormBaseID:	WBGene00017431	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	582	Identity:	146/582 - (25%)
Similarity:	245/582 - (42%)	Gaps:	104/582 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC-------- 89
            |..|   |.|||:..:  :|:.:...:.|||:|:||||||||:.|.....|..::||
Worm    18 KASC---GPVRGNIYK--HDDVIVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACV 77

  Fly    90 --------TYPRAKPMQKHFVLSIVEGSEDCLYLNVYSKRLRSDK---PLPVIVWIYGGGFQFGE 143
                    ..||....::          ..||.|||::.|..|.:   ..||:|:|:|||::..
Worm    78 QTGGFEQIAGPRTPTPEE----------AGCLTLNVFTPRNASSEFKNGRPVMVYIHGGGYELC- 131

  Fly   144 AGRDF--YSPDYFMQ-QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQ 205
            |..||  ||....:. :|||||:.|||:|..|||:..|.  ..|||.||.||.:||:|:.::|:.
Worm   132 ASSDFCAYSLSGTLPLKDVVVVSINYRLGVFGFLTTGDN--VCPGNFGLWDQTLALKWVQKHISS 194

  Fly   206 FNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWA--YRLACQL 268
            |.|||..:||.|:|||.||...|..:..:|.||.:.|..||:..|::|...|...|  :|...:.
Worm   195 FGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRASENQAKIFREFAEF 259

  Fly   269 -GYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHRE 332
             |:||.::......|.:::|.:....:|                :...:..::|   .:|....:
Worm   260 HGFSGRDSSALFKWYQEQSPETLSNVKG----------------YKKSISGFLT---FIPNLDGD 305

  Fly   333 MLP---EAWGNDLP---LILGGNSFEGLFSYQSTLHDEEHMLSAFE------VLIPREIREKSTQ 385
            ..|   :....:.|   ::.|...:|||..        ..|..||.      .|:|:.|..|...
Worm   306 FFPKPLDELRKEAPKKQMMTGVTEYEGLML--------ASMNPAFSPADVGLTLMPQGIYGKDVV 362

  Fly   386 SHLKDLLRQF---KVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRF 447
            |:..::.:.|   .|:..|.:....|....| ..|..:.|..|:.:.......|  ....|.|.|
Worm   363 SNPDEIQKIFYEKYVEGVDKSDELAMRKKLC-EALGDEFFNVGVIQAAKNAAKH--GNEVYFYTF 424

  Fly   448 DVDSP-HFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARND 511
            :..:| .|..:..:|   ..:...|..:|.||....:.:|.:.:..:.:.::....::..||:..
Worm   425 EYVNPDSFGMWDGMM---PFKAAVHCTELRYLLGEGVYSKFEPTEEDRKVMETTTTLFSNFAKYG 486

  Fly   512 NPNCPQIGPTTWEALDEKGPQMCLNIG------------KQLEFIVLPESKQNRIWDRLYDK 561
            |||........||......|:....|.            .:::|:...:...::..:.:|.|
Worm   487 NPNGKGATAEIWEKYSLNRPERHYRISYPKCEMRDVYHEGRIQFLEKIDGDSDKYQELVYGK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	143/560 (26%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	52/121 (43%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	143/553 (26%)
cest-33	NP_504621.1	Aes	<103..>224	CDD:223730	52/123 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.710