DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cest-24

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	594	Identity:	186/594 - (31%)
Similarity:	267/594 - (44%)	Gaps:	112/594 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-Y 91
            |..:..:|..:.|.:.|.|.:|. ..::...|.|||:|:||||||||:.||||..|.|:|.|. |
Worm    91 GKSENAIVRVQQGLLEGFRVKTA-KGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWEGIRKCNKY 154

  Fly    92 PRA---KPMQKHFVLSIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSP-- 151
            |..   |.|.....|.....|||||||||::.::|.||..||:.:|:|||:....|.|  |:.
Worm   155 PNRSIHKEMPWDKALPSANQSEDCLYLNVFAPKIREDKKYPVLFYIHGGGYVMDSAER--YTAKN 217

  Fly   152 --DYFMQQDVVVVTFNYRVGALGFLSLADRDLDV-PGNAGLKDQVMALRWISQNIAQFNGDPQNI 213
              ...:.::::||||:||:|.|||||..|   || |||.||.|.:.|:||:..||:.|.|||:||
Worm   218 ICKLLVSREIIVVTFHYRLGFLGFLSTGD---DVCPGNYGLFDMLEAMRWVHANISSFGGDPENI 279

  Fly   214 TVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA-------NEPSGRWAYRLAC--QLG 269
            |:.|:|||||:...|..:..|:|||.:.|:..|:.:|.||       .|...:||.||..  ||.
Worm   280 TLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSNHDIREYCKKWAKRLGWKPQLN 344

  Fly   270 YSGSENEK-EVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREM 333
            |:....|. ::|.:....|.|::   |:|:.......:....|..||::             .|:
Worm   345 YANKREESVDIFNFFNGLPTSKL---GMTMFFSNTIFKECQLPLAPVID-------------GEI 393

  Fly   334 LPEAWGNDL----------PLILGGNSFEG-LFSYQSTLH-DEEHMLSAFEVLIPREIREKSTQS 386
            ||    :||          |.::||..:|. ||.....|. .|:.:.||.:||     ..|:..|
Worm   394 LP----HDLKVLRETQEHVPSLVGGGEYEALLFCAIGLLRGTEKEINSAIDVL-----SRKNRLS 449

  Fly   387 HLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFW--HGIHRTVLARLSHAPATPTYLYRFDV 449
            ..|......||.....|.|...:..:...:..:...:  :|.:|  ..|.........|.|.||
Worm   450 RSKIEAMTEKVYGDSPALRADSKARKMFFVQLISDIFANYGNYR--FMRDCQQRGVECYGYSFD- 511

  Fly   450 DSPHFNHFRQVMCG--KHV---RGVSHADDLSYLF--YHILA----NKVDK--SSM--EYQTIQR 499
                  |..:.|.|  :||   .|.:|..:|||||  .::.|    ||.||  |.|  :|.|
Worm   512 ------HQSKQMWGWLQHVVPFTGGTHTSELSYLFDCNYMSAPLGMNKTDKVVSGMTADYFT--- 567

  Fly   500 LVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDR------- 557
                  .|.:...||.|......||.:......|     |.:.....||.|......|
Worm   568 ------NFVKFGTPNGPNSQLPKWERISPDDEHM-----KLISIKPEPEMKTTVYGYRMQNFEDH 621

  Fly   558 ---LYDKND 563
               ||::.|
Worm   622 LGMLYEEKD 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	179/560 (32%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	53/120 (44%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	180/564 (32%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	47/106 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870