DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cest-32

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	143/531 - (26%)
Similarity:	237/531 - (44%)	Gaps:	90/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC-TYPRAKPMQKHFVL 103
            |.|.|:..|  :|:::...:.|||||:.|:.||||:.|.....|....:| .|....|...|.:.
Worm    22 GPVIGNIYR--HDDKIVNGYLGIPFAKAPICELRFKKPVEAEKWTKPLNCHKYGPGCPQSGHMIS 84

  Fly   104 SIV-----EGSED-CLYLNVYSKRLRSDK---PLPVIVWIYGGGFQFGEAGRDFYS--PDYFMQ- 156
            :::     |.:|| ||.||:::...:|::   .||::|:.:||||:.|     |.|  .||.:.
Worm    85 NLLPPGYREFAEDNCLNLNIFAPSWKSEEFPNGLPIMVYFHGGGFEIG-----FSSMFDDYSLSG 144

  Fly   157 ----QDVVVVTFNYRVGALGFLSLADRDLDVP-GNAGLKDQVMALRWISQNIAQFNGDPQNITVM 216
                :||:|||.|||||.|||::..|   :|. ||.||.||.:||:|:.::|..|.|:|..:||.
Worm   145 TLPLKDVIVVTANYRVGPLGFMTTGD---EVSRGNYGLWDQTLALKWVQEHIKSFGGNPNIVTVC 206

  Fly   217 GESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA---NEPSGRWAYRLACQLGYSGSENEKE 278
            |.|||..|...|..:..:..|||:.:..|||.|||::   .|.........|...||.|.::| .
Worm   207 GTSAGGVSAGLLALSPHSNKLFHRFMAMSGSAFCEFSIRTKEQEAEIFRNFAKHHGYEGEDSE-S 270

  Fly   279 VFRYLQKAPASEMAAQGITLVSQE----ERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWG 339
            :..:.:..|.|:.         ||    |::......|.|..:     ....|:...|:..||
Worm   271 LLEWYKSQPLSKF---------QETATFEKKASGFLTFIPNFD-----GDFFPKPFDELSREA-- 319

  Fly   340 NDLPLILGGNSFEG---LFSYQSTLHDEEHMLSAFEVLIPR---EIREKSTQSHLKDLLRQFKVD 398
            ..|..:...:.:||   |..:||..:|.:.:.|:|...:..   :::::..:.::|::.:
Worm   320 PKLDAMATVDEYEGLGFLTMFQSRRNDMDIIKSSFGSDVVENAVDVQKRIMEFYMKNIDK----- 379

  Fly   399 NFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDV-----DSPHFNHFR 458
            |.|.|...|:       |..:...|..|......:.|....:..||..||.     :.|:...|
Worm   380 NDDKAVEKRL-------IQLISDSWFNIGALETVKTSTKYGSNAYLGSFDYYNMGSNDPYATWF- 436

  Fly   459 QVMCGKHVRGVSHADDLSYLFYHILANKVDKSS---MEYQTIQRLVGMWVAFARNDNPNCPQIGP 520
                  ..:..:|..:|.|:    |...:.|.|   .|::.|..:..:...|.:..|||... ||
Worm   437 ------PFKAANHGSELKYM----LGEGMGKFSPIEEEFKVIDMMGTLTANFVKYGNPNGIN-GP 490

  Fly   521 TTWEALDEKGP 531
            ..|:....:.|
Worm   491 ELWKKYTPEKP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	143/531 (27%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	49/126 (39%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	143/531 (27%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	49/130 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640