Protein Alignment alpha-Est1 and cest-4

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_501043.1
• Gene: cest-4 / 177445
• WormBaseID: WBGene00015930
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 133/590 - (22%)
• Similarity: 232/590 - (39%)
• Gaps: 159/590 - (26%)

  Fly    31 QTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCTYPRAK 95
            ::.:|.|..||:.|.:..:      :..|:.||.|:||:|:|||:.|:||..|.|||:.
 Worm    25 KSAIVSTSLGQIDGDQIGS------FHLFKHIPLAKPPIGKLRFQKPEPPEKWTGVRNA------ 77

  Fly    96 PMQKHFVLSIVEGS-----------EDCLYLNVYS--KRLRSDKPLPVIVWIYGGGFQFGEA--G 145
               |.:..:.:..|           ||||::|:::  |.|:| |...|:.:.:|||..:..|  .
 Worm    78 ---KAYGPACISNSSVSTSPQKWIDEDCLHINIFTSDKCLKS-KDCAVVTYFHGGGLMYDSAVMF 138

  Fly   146 RDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDP 210
            .|.|....|:.|||::....:|:|......:.|:.: .|.|..|.|.::.:.::...|..|.|:.
 Worm   139 NDTYLLGTFVNQDVIIAIPAFRLGIFSHFVVEDQSI-APTNLALYDILLGVEFVKNEIHNFGGNN 202

  Fly   211 QNITVMGESAGAASVHALMTTEQTR---GLFHKAI-MQSGSMF--CEWANEPSGRWAYRLACQ-- 267
            |..|:||.|.|.:.|:.|..:.:..   .||.::| |.||..|  .|...:.:.|:|....|.
 Worm   203 QKNTIMGHSYGGSIVNILTFSSKINHDLSLFQQSICMSSGHDFETLEIQIQKTNRFAKHAGCTVP 267

  Fly   268 --LGYSGSENEKEVFRY--LQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPR 328
              :....:..:.:::|.  ||...|.|:    :.:....|...|..:.:....||.|..   :|
 Worm   268 SIIEKKMTTRQSDLYRMKCLQNKDALEL----LRVQRLLEDEGYPTYGYLVQREPLIQE---IP- 324

  Fly   329 CHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLR 393
             ::|.:...  ..:|::.|           .|.::.:|..:      |:.|.:.....:.:::..
 Worm   325 -YQEFMKSP--KKIPMLTG-----------CTRYEMDHSPA------PKPIGQALGFENPEEVYM 369

  Fly   394 QFKVD---------NFDDATRG-----RMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYL 444
            :|:.|         |..|.|:.     |:..|..|                      :...|.||
 Worm   370 KFRKDWDDEVYEFGNHSDETQAIMVQVRVRVNNLL----------------------SKNVPAYL 412

  Fly   445 YRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSME------YQTI------ 497
            |.:...             ||.|   |.||   |||.:..::.:|...|      |:||
 Worm   413 YEYTYP-------------KHAR---HTDD---LFYLMGVHRFEKDENEIELGKVYETIFMNFAK 458

  Fly   498 --QRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIW--DRL 558
              ....|..:|.|.|::     .....|:....:.|||      :.:|    |.|....|  |.:
 Worm   459 FGDPKEGFELANAENES-----YYEVYWDGETGERPQM------KTKF----EEKIINYWLKDMV 508

  Fly   559 -YDKN 562
             |||:
 Worm   509 EYDKH 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	128/578 (22%)
cest-4	NP_501043.1	alpha/beta hydrolases	26..503	CDD:473884	128/577 (22%)