DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cest-5.2

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_501021.3	Gene:	cest-5.2 / 177428	WormBaseID:	WBGene00015284	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	141/562 - (25%)
Similarity:	229/562 - (40%)	Gaps:	107/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKP 96
            :::.|..|::.|.:      ...|..|..||||:||:|.|||:.|:....|.||.:.| |..|..
Worm    22 RIIKTSLGRLEGKQ------SGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPACM 80

  Fly    97 MQKHFVLSIVEG-SEDCLYLNVYS--KRLRSDKPLPVIVWIYGGGFQFGEA--GRDFYSPDYFMQ 156
            ....:..|..:. .||||::|:::  |.|:| |...|:|:|:||...|..|  ..|.:..:.|::
Worm    81 SNSTWTQSPQKWVDEDCLHVNIFTSDKCLKS-KDCAVVVYIHGGEIVFDSAVMFNDTFLLESFVK 144

  Fly   157 QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAG 221
            |||::|...:|:|.....::.|::: .|.|..|.|.::|..::...|..|.||.|.||:.|.|.|
Worm   145 QDVILVIPAFRLGIFSHFTVHDQNI-APNNLALYDIILAQEFVKSEIHNFGGDIQKITLFGHSYG 208

  Fly   222 A--ASVHALMT-TEQTRGLFHKAIMQSGSMFCEWANEP---SGRWAYRLACQL------GYSGSE 274
            .  ||:.|..: ..|...||.:.|:.|.:.:.:...|.   |.|......|.:      ..:.|:
Worm   209 GTIASMMAFSSEINQDLSLFQRIIVMSANQYFDTLEEQIERSDRVVKHAGCSVPTNLARKMNRSQ 273

  Fly   275 NEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPR-CHREML--PE 336
            .||.:.:.|||....|:    :::....|...|      |.:...:.|..:.|. ...|||  |:
Worm   274 KEKYMMKCLQKLSGMEL----LSVQRSLEEAGY------PDIGNLVLRGPLFPDVTSLEMLESPK 328

  Fly   337 AWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSA-FEVLIPREIREKSTQSHLKDLLRQ-FKVDN 399
            .    :|::.|...||      |...||.|.:.. |.:..|.|..||    :.|||... |...|
Worm   329 M----IPMLAGCTKFE------SDDEDETHFIGKHFGLENPIECDEK----YRKDLENGIFDRQN 379

  Fly   400 FDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGK 464
            ..|.|:..|...: |.:..::.  ||:              |.|||.|......|
Worm   380 HSDKTQAIMVPTK-LRVDQLRK--HGV--------------PAYLYEFTYPKHAF---------- 417

  Fly   465 HVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNP----NCPQIGPTT--- 522
                  |.|||.|:. .|...:.|::....:.:.|  .|.:.|.:...|    ....:..:|
Worm   418 ------HTDDLYYIM-GIHPFEKDENEEHLEKVYR--NMLINFIKFGEPGMGFEMSDLNESTYFE 473

  Fly   523 --WEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYDKN 562
              |.....:.|:|.....:.:....|.|..:       ||:|
Worm   474 IYWNETTGQKPRMRKRFEENITNYWLKEMME-------YDRN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	136/539 (25%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	38/122 (31%)
cest-5.2	NP_501021.3	Abhydrolase	23..498	CDD:389770	136/542 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740