Protein Alignment alpha-Est1 and cest-5.2

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 141/562 - (25%)
• Similarity: 229/562 - (40%)
• Gaps: 107/562 - (19%)

  Fly    33 KVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKP 96
            :::.|..|::.|.:      ...|..|..||||:||:|.|||:.|:....|.||.:.| |..|..
 Worm    22 RIIKTSLGRLEGKQ------SGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPACM 80

  Fly    97 MQKHFVLSIVEG-SEDCLYLNVYS--KRLRSDKPLPVIVWIYGGGFQFGEA--GRDFYSPDYFMQ 156
            ....:..|..:. .||||::|:::  |.|:| |...|:|:|:||...|..|  ..|.:..:.|::
 Worm    81 SNSTWTQSPQKWVDEDCLHVNIFTSDKCLKS-KDCAVVVYIHGGEIVFDSAVMFNDTFLLESFVK 144

  Fly   157 QDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAG 221
            |||::|...:|:|.....::.|::: .|.|..|.|.::|..::...|..|.||.|.||:.|.|.|
 Worm   145 QDVILVIPAFRLGIFSHFTVHDQNI-APNNLALYDIILAQEFVKSEIHNFGGDIQKITLFGHSYG 208

  Fly   222 A--ASVHALMT-TEQTRGLFHKAIMQSGSMFCEWANEP---SGRWAYRLACQL------GYSGSE 274
            .  ||:.|..: ..|...||.:.|:.|.:.:.:...|.   |.|......|.:      ..:.|:
 Worm   209 GTIASMMAFSSEINQDLSLFQRIIVMSANQYFDTLEEQIERSDRVVKHAGCSVPTNLARKMNRSQ 273

  Fly   275 NEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPR-CHREML--PE 336
            .||.:.:.|||....|:    :::....|...|      |.:...:.|..:.|. ...|||  |:
 Worm   274 KEKYMMKCLQKLSGMEL----LSVQRSLEEAGY------PDIGNLVLRGPLFPDVTSLEMLESPK 328

  Fly   337 AWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSA-FEVLIPREIREKSTQSHLKDLLRQ-FKVDN 399
            .    :|::.|...||      |...||.|.:.. |.:..|.|..||    :.|||... |...|
 Worm   329 M----IPMLAGCTKFE------SDDEDETHFIGKHFGLENPIECDEK----YRKDLENGIFDRQN 379

  Fly   400 FDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGK 464
            ..|.|:..|...: |.:..::.  ||:              |.|||.|......|
 Worm   380 HSDKTQAIMVPTK-LRVDQLRK--HGV--------------PAYLYEFTYPKHAF---------- 417

  Fly   465 HVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNP----NCPQIGPTT--- 522
                  |.|||.|:. .|...:.|::....:.:.|  .|.:.|.:...|    ....:..:|
 Worm   418 ------HTDDLYYIM-GIHPFEKDENEEHLEKVYR--NMLINFIKFGEPGMGFEMSDLNESTYFE 473

  Fly   523 --WEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYDKN 562
              |.....:.|:|.....:.:....|.|..:       ||:|
 Worm   474 IYWNETTGQKPRMRKRFEENITNYWLKEMME-------YDRN 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	138/553 (25%)
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	136/543 (25%)