Protein Alignment alpha-Est1 and cest-25

DIOPT Version :10

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 182/588 - (30%)
• Similarity: 268/588 - (45%)
• Gaps: 102/588 - (17%)

  Fly    13 MGTKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYD-EEMYFAFEGIPFAQPPVGELRFRA 76
            ||..:..|....|    ..::.|.|..|.:.|  ||.::: |:...||:|||:|.||:|.|||..
 Worm     1 MGGTVSKHTTPHY----PPSRQVLTSYGPIEG--RRLIHEGEKQVDAFQGIPYAAPPIGNLRFAL 59

  Fly    77 PQPPHPWLGVRDCTYPRAKPMQKHFVLS--IVEGSEDCLYLNVYSK--RLRSDKPLPVIVWIYGG 137
            |||...|..||:.....|:.:||..|||  ....|||.|.||:::.  ..:::...|||::|:||
 Worm    60 PQPHEKWTEVRETKSFGARGIQKDHVLSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGG 124

  Fly   138 GFQFGEAGR--DFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWIS 200
            ||....|.:  |.....:.:.:||||||..||:|.|||.:..|.  .:|.|..|.|.|.||:|:.
 Worm   125 GFVSDSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFWTTGDS--SIPDNVALHDMVFALKWVK 187

  Fly   201 QNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAYR-L 264
            :||..|||||.|||:||:|||.|||..|..:..:|.||.|.|...|:..|.||..|....|.| .
 Worm   188 ENIGLFNGDPNNITLMGQSAGGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNR 252

  Fly   265 ACQLGYSGSENEKEVFRYLQKAPASEMA-AQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPR 328
            |.::|.....|..:....|::.||.:.| |..:..|..:...:.::.|      .|  .:..:||
 Worm   253 AQEIGVFDGMNTLDWVEKLRELPADKFASALNMEAVDTKTDPELLIGP------KY--DNLFIPR 309

  Fly   329 CHREMLPEAWGNDLPLILGGNSFEGL-FSY-----QSTLHDEEHMLSAF--EVLIP---REIREK 382
            ...|:..||  ...|.:||....||| |::     :..||..:..:||.  |.|.|   |:.:||
 Worm   310 PVMELRKEA--PMKPRLLGCAKSEGLVFAFFGLNTKHPLHAVQQDVSAILSEKLFPLKARDYQEK 372

  Fly   383 STQ-------SHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPAT 440
            :.:       .|.|:..::..||...|:            .|:|     ||.:.||..|...|:|
 Worm   373 ALEKLIEIGTDHSKEEWQRAMVDLKGDS------------FLNV-----GIQQNVLDVLETQPST 420

  Fly   441 PTYLYRFDVDSPHFNHFRQVMCGKHVRGV----------SHADDLSYLFYHILANKVDKSSMEYQ 495
            |.|:|.||            .|.....|:          :|..|:||:..:.:.|..|.:..:|:
 Worm   421 PIYMYSFD------------YCNPKAYGIMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYK 473

  Fly   496 TIQRLVGMWVAFARNDNPNCPQIG--------PTTWEALDEKGPQ--MCLNIGKQLEFIVLPESK 550
            .|:....:|..||:..|||    |        ...||....:.||  |.|.:..:|..:.    |
 Worm   474 MIEITTRLWTNFAKYGNPN----GEGDDVAHLEEKWEPATIESPQTHMALTLQPKLHHVY----K 530

  Fly   551 QNR 553
            |.|
 Worm   531 QGR 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	178/570 (31%)
cest-25	NP_497609.1	COesterase	15..536	CDD:395084	178/570 (31%)