DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cest-25

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	588	Identity:	182/588 - (30%)
Similarity:	268/588 - (45%)	Gaps:	102/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MGTKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYD-EEMYFAFEGIPFAQPPVGELRFRA 76
            ||..:..|....|    ..::.|.|..|.:.|  ||.::: |:...||:|||:|.||:|.|||..
Worm     1 MGGTVSKHTTPHY----PPSRQVLTSYGPIEG--RRLIHEGEKQVDAFQGIPYAAPPIGNLRFAL 59

  Fly    77 PQPPHPWLGVRDCTYPRAKPMQKHFVLS--IVEGSEDCLYLNVYSK--RLRSDKPLPVIVWIYGG 137
            |||...|..||:.....|:.:||..|||  ....|||.|.||:::.  ..:::...|||::|:||
Worm    60 PQPHEKWTEVRETKSFGARGIQKDHVLSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGG 124

  Fly   138 GFQFGEAGR--DFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWIS 200
            ||....|.:  |.....:.:.:||||||..||:|.|||.:..|.  .:|.|..|.|.|.||:|:.
Worm   125 GFVSDSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFWTTGDS--SIPDNVALHDMVFALKWVK 187

  Fly   201 QNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSGRWAYR-L 264
            :||..|||||.|||:||:|||.|||..|..:..:|.||.|.|...|:..|.||..|....|.| .
Worm   188 ENIGLFNGDPNNITLMGQSAGGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNR 252

  Fly   265 ACQLGYSGSENEKEVFRYLQKAPASEMA-AQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPR 328
            |.::|.....|..:....|::.||.:.| |..:..|..:...:.::.|      .|  .:..:||
Worm   253 AQEIGVFDGMNTLDWVEKLRELPADKFASALNMEAVDTKTDPELLIGP------KY--DNLFIPR 309

  Fly   329 CHREMLPEAWGNDLPLILGGNSFEGL-FSY-----QSTLHDEEHMLSAF--EVLIP---REIREK 382
            ...|:..||  ...|.:||....||| |::     :..||..:..:||.  |.|.|   |:.:||
Worm   310 PVMELRKEA--PMKPRLLGCAKSEGLVFAFFGLNTKHPLHAVQQDVSAILSEKLFPLKARDYQEK 372

  Fly   383 STQ-------SHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPAT 440
            :.:       .|.|:..::..||...|:            .|:|     ||.:.||..|...|:|
Worm   373 ALEKLIEIGTDHSKEEWQRAMVDLKGDS------------FLNV-----GIQQNVLDVLETQPST 420

  Fly   441 PTYLYRFDVDSPHFNHFRQVMCGKHVRGV----------SHADDLSYLFYHILANKVDKSSMEYQ 495
            |.|:|.||            .|.....|:          :|..|:||:..:.:.|..|.:..:|:
Worm   421 PIYMYSFD------------YCNPKAYGIMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYK 473

  Fly   496 TIQRLVGMWVAFARNDNPNCPQIG--------PTTWEALDEKGPQ--MCLNIGKQLEFIVLPESK 550
            .|:....:|..||:..|||    |        ...||....:.||  |.|.:..:|..:.    |
Worm   474 MIEITTRLWTNFAKYGNPN----GEGDDVAHLEEKWEPATIESPQTHMALTLQPKLHHVY----K 530

  Fly   551 QNR 553
            |.|
Worm   531 QGR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	174/559 (31%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	50/119 (42%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	178/567 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.710