DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cest-27

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	150/554 - (27%)
Similarity:	248/554 - (44%)	Gaps:	70/554 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQVRGHRRRTLYDEE---MYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-----YPRAKP 96
            |.::|    ..|::|   :...|.|||:|:||:|.|||:.|.....|....||.     .|:...
Worm    33 GPIKG----VGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDE 93

  Fly    97 MQKHFVLSIVEGSEDCLYLNVYSKRLRSDK---PLPVIVWIYGGGFQFGEAGRDFYSPDY----- 153
            :...||.::.:..|.||.|||::.:..|::   ..||:|:|:||||....      |.:|
Worm    94 LLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHS------SSNYGCASI 152

  Fly   154 ---FMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITV 215
               ...:||||||.|||:|.|||.:..|.  ...||.||.||..||.|:.:||..|.|||.|:|:
Worm   153 ARNLCTKDVVVVTINYRLGVLGFFTTGDE--VCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTI 215

  Fly   216 MGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA---NEPSGRWAYRLACQLGYSGSENEK 277
            .|:|||.|||..|..:..:||||::||..:|:..|::|   :|...:.:...|..||:.|.:|:.
Worm   216 FGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDDNDS 280

  Fly   278 E-VFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGND 341
            | :.:::.:.|..:: ..||......:..|.....|.|..:     ....|:...::..||  ..
Worm   281 EDLLQFIDQQPLYKI-EMGINPKRGFKHSQAGSLYFVPNFD-----GDFFPKPLNQLRKEA--PK 337

  Fly   342 LPLILGGNSFEGLFSYQ-STLHDEEHMLSAFEVLIPREIREKSTQSHLKDLLRQ-----FKVDNF 400
            :.::.|...:||||... ..|......:..|   :.|..:|........|:|:.     ||..:.
Worm   338 MQIMTGTTKYEGLFFIALGALSKNPEGIKKF---MGRIFKECDYGERADDVLQMVYDFYFKGVHP 399

  Fly   401 DDATRGRMEFNECLHILSVKHFWHGIHR--TVLARLSHAPATPTYLYRFDV-DSPHFNHFRQVMC 462
            .|..:...:..:.:...|:.   :|.:|  .::..|.|    ..|.|:||. :|..|..||.::
Worm   400 KDHEKNMHQIVKFIGDYSIN---YGTYRLANIMTDLQH----DVYFYQFDYHNSAGFGVFRWLL- 456

  Fly   463 GKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALD 527
              ...|.:|..::.|:....:.:|...:..:.:.:..:...:..||:..|||........|:..|
Worm   457 --PFLGSTHCTEMRYVLGKGIISKFRPNDNDKKMLHVMTTYFTNFAKYGNPNGENQETGEWQKHD 519

  Fly   528 EKGPQMCLNIGKQLEFIVLPESKQNR---IWDRL 558
            ...|.....|  .|:...:.|..|.|   :||:|
Worm   520 SAHPFRHFKI--DLDDSEMVEDYQERRAELWDKL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	143/532 (27%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	51/126 (40%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	145/542 (27%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	67/176 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750