Protein Alignment alpha-Est1 and Nlgn3

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_599163.2
• Gene: Nlgn3 / 171297
• RGDID: 621119
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 672
• Identity: 185/672 - (27%)
• Similarity: 281/672 - (41%)
• Gaps: 141/672 - (20%)

  Fly     1 MEIRVGVGDLLKMGTKLIGHKI--------VQYRLGTK-QTKVVCTRDGQVRGHR----RRTLYD 52
            |.:::|:..|....|..:|..:        :..|..|: ....|.|..|::||.|    ...|..
  Rat     1 MWLQLGLPSLSLSPTPTVGRSLCLILWFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGP 65

  Fly    53 EEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPMQKHFV-------------L 103
            .:.|.   |:|:|.||:||.||..|:||..|.|:|:.| :|...|...|..             |
  Rat    66 VDQYL---GVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANL 127

  Fly   104 SIV-----EGSEDCLYLNVY-----SKRLRSD---KP---------------------------- 127
            .||     |.:|||||||||     .||:..:   ||
  Rat   128 DIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDE 192

  Fly   128 -------LPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPG 185
                   .||:|:|:||.:..| .|............:|:|:|.|||||.|||||..|:  ...|
  Rat   193 DIRDSGAKPVMVYIHGGSYMEG-TGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQ--AAKG 254

  Fly   186 NAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFC 250
            |.||.||:.||||:|:|||.|.|||:.|||.|...||:.|..|..:..:.|||.:||:||||...
  Rat   255 NYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALS 319

  Fly   251 EWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTP 314
            .|| |....::...||.::|.:..:....|....||: |.|:..|.|     :..|.:|.|
  Rat   320 SWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKS-AKELVEQDI-----QPARYHVAF---- 374

  Fly   315 VVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSA-FEVLIPRE 378
              .|.|..| |:|.....::.:....:..::||.|..|||...:..:..|:.:... |:..:...
  Rat   375 --GPVIDGD-VIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNF 436

  Fly   379 IREKSTQSHLKDLLRQ-FKVDNFDDATRGRMEF-NECLHILSVKHFWHGIHRTVLARLSHAP-AT 440
            :.........||.||: .|....|.|.|...|. .:.|..|...|.|  :..:|:....||. .:
  Rat   437 VDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQW--VEPSVVTADLHARYGS 499

  Fly   441 PTYLYRFDVDSPHFNHFRQVMCGKHV-RGVSHADDLSYLFYHILANKVD-------KSSMEYQTI 497
            |||.|.|      ::|.:.:|  |.. ...:|.|::.|:|...:....|       |:.:....:
  Rat   500 PTYFYAF------YHHCQSLM--KPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAV 556

  Fly   498 QRLVGMWVAFARNDNPNCP-------------QIGPTTWEALDEKGPQMCLNIGKQLEFIVLPES 549
              ::..|..||:..:||.|             :.....|...:.: .|:.|:||  |:..|....
  Rat   557 --VMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPR-DQLYLHIG--LKPRVRDHY 616

  Fly   550 KQNRI--W----DRLYDKNDLF 565
            :..::  |    ..||:.:|:|
  Rat   617 RATKVAFWKHLVPHLYNLHDMF 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	172/605 (28%)
		Aes	<117..>233	CDD:223730	54/158 (34%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	173/617 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..195		0/25 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..691

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740