Protein Alignment alpha-Est1 and Ces3b

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 610
• Identity: 183/610 - (30%)
• Similarity: 252/610 - (41%)
• Gaps: 133/610 - (21%)

  Fly    10 LLKMGTKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRF 74
            ||...|.:.|.|::|..:.|..        |:|||.:......:.|...|.||||||.|||.|||
Mouse    22 LLAFVTTVTGPKVIQPEVDTPL--------GRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRF 78

  Fly    75 RAPQPPHPWLGVRD-------CTYPRAKPMQKHFVLS----IVEGSEDCLYLNVYS-KRLRSDKP 127
            .||.||.||.||||       |.....|.:...|.|:    |...|||||.||:|| ..:.:...
Mouse    79 SAPLPPQPWEGVRDASINPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDK 143

  Fly   128 LPVIVWIYGGGFQFGEAGRDFYSPD---YFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGL 189
            .||:|||:||....|.:    .|.|   .....||||||..||:|..||||..|:.:  |||.|.
Mouse   144 RPVMVWIHGGSLLVGSS----TSQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHM--PGNRGF 202

  Fly   190 KDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSG---SMFCE 251
            .|.|.||||:..|||.|.|||..:|:.|.|||...|.:|..:..:.||||:||.|||   ::..|
Mouse   203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMME 267

  Fly   252 ----WANEPSGRWAYRLACQLGYSGSENEKEVFR-YLQKAPASEMAAQGITLVSQEERRQYVLFP 311
                |..  :..:|..:||     ||.:..|:.: .|||        :|..|:.|:.
Mouse   268 DMKPWPE--AQNFANSVAC-----GSASPAELVQCLLQK--------EGKDLIKQKN-------- 309

  Fly   312 FTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILG--GNSFEGLFSYQSTLHDEEHMLSAFEVL 374
               |...||..|...|:...::|.:.....:|.:||  .:.|..|......:.|:...||..::|
Mouse   310 ---VNISYIVNDSFFPQRPEKLLADQQFPTVPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLL 371

  Fly   375 -----------IPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECL----HILSVKHFWH 424
                       :|.||.......:|         ||..|.:..|..|.|.|    .|:...:|
Mouse   372 EISRPFLAIMEVPPEIMPTVIDEYL---------DNGSDQSATRYAFQELLGDISFIIPTLNF-- 425

  Fly   425 GIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDK 489
                   ::.......|.:||.|......|..|:....     ...||.:.|::|.....  .|:
Mouse   426 -------SKYLRDAGCPVFLYEFQHTPSSFAKFKPAWV-----KADHASENSFVFGGPFL--TDE 476

  Fly   490 SSM---------EYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQ----- 540
            ||:         |.|....::..|..|||..|||...:.|  |..|::.  :..|.||.:
Mouse   477 SSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPP--WPQLNQL--EQYLEIGLESRTGV 537

  Fly   541 ------LEF--IVLPESKQNRIWDR 557
                  |:|  ..||...|.  |.|
Mouse   538 KLKKGRLQFWTETLPRKIQE--WHR 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	170/572 (30%)
		Aes	<117..>233	CDD:223730	50/119 (42%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	172/579 (30%)
		Aes	75..>245	CDD:223730	75/175 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832487
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740